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Articles Published Processes
10/14/2025 7:42:32 AM | Browse: 6 | Download: 45
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Received |
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2025-05-14 09:00 |
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Peer-Review Started |
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2025-05-14 09:00 |
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To Make the First Decision |
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Return for Revision |
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2025-06-06 03:06 |
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Revised |
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2025-06-19 00:55 |
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Second Decision |
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2025-08-07 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-07 07:15 |
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Articles in Press |
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2025-08-07 07:15 |
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Publication Fee Transferred |
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2025-06-26 05:12 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-29 00:23 |
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Publish the Manuscript Online |
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2025-10-14 07:42 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Molecular mechanism of modified Yigong San formula against colorectal cancer via EZH2/METTL3/SOX4 pathway-mediated apoptosis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Jing Wang, Xin-Wei Zhang, Bo-Wen Tang, Zheng Li and Nan Song |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Liaoning Provincial Science and Technology Department Project |
2023JH2/101700149 |
| Open Fund Project of Liaoning University of Traditional Chinese Medicine |
zyzx2205 |
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| Corresponding Author |
Nan Song, Professor, Medical Laboratory Science School, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China. cpcool@126.com |
| Key Words |
Apoptosis; Colorectal cancer; Enhancer of zeste homolog 2/methyltransferase-like 3/SRY-box transcription factor 4 pathway; Yigong San; Cell proliferation; Traditional Chinese medicine |
| Core Tip |
In this study, SW-480 cells were used as experimental subjects. Quantitative reverse transcription polymerase chain reaction, western blot, cell scratch assay, flow cytometry and other experimental methods were used to explore the expression of genes such as methyltransferase-like 3 (METTL3), enhancer of zeste homolog 2 (EZH2), SRY-box transcription factor 4 (SOX4), B-cell lymphoma 2, Bax and other genes as well as proteins, and to analyze that Isokongsan plus formula mediated the cellular apoptosis through EZH2/METTL3/SOX4 apoptosis against colorectal cancer through EZH2/METTL3/SOX4. |
| Publish Date |
2025-10-14 07:42 |
| Citation |
<p>Wang J, Zhang XW, Tang BW, Li Z, Song N. Molecular mechanism of modified Yigong San formula against colorectal cancer via EZH2/METTL3/SOX4 pathway-mediated apoptosis. <i>World J Gastrointest Oncol</i> 2025; 17(10): 108410</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i10/108410.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i10.108410 |
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