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8/27/2025 9:21:09 AM | Browse: 115 | Download: 300
Publication Name World Journal of Hepatology
Manuscript ID 108474
Country Türkiye
Received
2025-04-15 11:28
Peer-Review Started
2025-04-15 11:29
First Decision by Editorial Office Director
2025-05-08 22:56
Return for Revision
2025-05-09 05:17
Revised
2025-05-09 06:29
Publication Fee Transferred
Second Decision by Editor
2025-07-02 02:38
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-07-02 06:59
Articles in Press
2025-07-02 06:59
Edit the Manuscript by Language Editor
2025-07-09 18:02
Typeset the Manuscript
2025-08-14 03:06
Publish the Manuscript Online
2025-08-27 09:21
ISSN 1948-5182 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Letter to the Editor
Article Title Iron metabolism and sepsis-associated liver injury: Methodological considerations and clinical perspectives
Manuscript Source Unsolicited Manuscript
All Author List Gokhan Koker
ORCID
Author(s) ORCID Number
Gokhan Koker http://orcid.org/0000-0003-1745-8002
Funding Agency and Grant Number
Corresponding Author Gokhan Koker, Assistant Professor, MD, Internal Medicine, University of Health and Sciences Antalya Training and Research Hospital, Varlık mah, Antalya 07050, Türkiye. gkhnkkr@gmail.com
Key Words Sepsis-associated liver injury; Iron metabolism; Hepcidin; Serum iron; Total iron-binding capacity; Prognostic markers; Biomarkers in critical illness; Liver imaging; Ferritin; Transferrin saturation
Core Tip This letter to the Editor provides commentary on a recent study addressing the relationship between iron metabolism and sepsis-associated liver injury (SALI). We highlight key methodological considerations, including the absence of hepcidin—a central iron-regulating hormone—in the biomarker panel, and the reliance solely on biochemical criteria for SALI diagnosis. We emphasize the importance of serial measurements and imaging-based confirmation. Our discussion aims to enhance clinical interpretation and guide future studies on the prognostic role of iron-related markers in critical care settings.
Publish Date 2025-08-27 09:21
Citation

Koker G. Iron metabolism and sepsis-associated liver injury: Methodological considerations and clinical perspectives. World J Hepatol 2025; 17(8): 108474

URL https://www.wjgnet.com/1948-5182/full/v17/i8/108474.htm
DOI https://dx.doi.org/10.4254/wjh.v17.i8.108474
Full Article (PDF) WJH-17-108474-with-cover.pdf
Manuscript File 108474_Auto_Edited_013722.docx
Answering Reviewers 108474-answering-reviewers.pdf
Audio Core Tip 108474-audio.mp3
Conflict-of-Interest Disclosure Form 108474-conflict-of-interest-statement.pdf
Copyright License Agreement 108474-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 108474-non-native-speakers.pdf
Peer-review Report 108474-peer-reviews.pdf
Scientific Misconduct Check 108474-scientific-misconduct-check.png
Scientific Editor Work List 108474-scientific-editor-work-list.pdf
CrossCheck Report 108474-crosscheck-report.pdf