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10/31/2025 3:02:53 PM | Browse: 12 | Download: 58
Publication Name World Journal of Clinical Pediatrics
Manuscript ID 108520
Country China
Received
2025-04-17 11:29
Peer-Review Started
2025-04-17 11:29
First Decision by Editorial Office Director
2025-05-01 02:18
Return for Revision
2025-05-01 02:18
Revised
2025-05-14 16:21
Publication Fee Transferred
Second Decision by Editor
2025-08-12 02:58
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-08-13 00:58
Articles in Press
2025-08-13 00:58
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-10-20 02:46
Publish the Manuscript Online
2025-10-31 15:02
ISSN 2219-2808 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Medicine, Research & Experimental
Manuscript Type Minireviews
Article Title Research on gamma globulin unresponsive Kawasaki disease: A review
Manuscript Source Invited Manuscript
All Author List Zu-Chuang Wu and Yan Pan
ORCID
Author(s) ORCID Number
Yan Pan http://orcid.org/0000-0003-0240-7085
Funding Agency and Grant Number
Corresponding Author Yan Pan, Researcher, Department of Pediatrics, The First Affiliated Hospital of Yangtze University, No. 55 Jianghan North Road, Shashi District, Jingzhou 434000, Hubei Province, China. woshipanyan@126.com
Key Words Kawasaki disease; Intravenous immunoglobulin resistance; Biomarkers; Immunomodulation; Coronary artery lesions
Core Tip Gamma globulin-unresponsive Kawasaki disease (KD) poses significant clinical challenges due to its complex pathophysiology and variable treatment outcomes. This review synthesizes current knowledge on epidemiology, IVIG resistance mechanisms, diagnostic criteria, and evolving therapeutic strategies (e.g., corticosteroids, biologics). Key controversies include optimal second-line therapies and long-term cardiovascular monitoring. Future directions emphasize targeted drug development and international collaboration to improve management of refractory KD.
Publish Date 2025-10-31 15:02
Citation

Wu ZC, Pan Y. Research on gamma globulin unresponsive Kawasaki disease: A review. World J Clin Pediatr 2025; 14(4): 108520

URL https://www.wjgnet.com/2219-2808/full/v14/i4/108520.htm
DOI https://dx.doi.org/10.5409/wjcp.v14.i4.108520
Full Article (PDF) WJCP-14-108520-with-cover.pdf
Manuscript File 108520_Auto_Edited_014418.docx
Answering Reviewers 108520-answering-reviewers.pdf
Audio Core Tip 108520-audio.mp3
Conflict-of-Interest Disclosure Form 108520-conflict-of-interest-statement.pdf
Copyright License Agreement 108520-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 108520-non-native-speakers.pdf
Peer-review Report 108520-peer-reviews.pdf
Scientific Misconduct Check 108520-scientific-misconduct-check.png
Scientific Editor Work List 108520-scientific-editor-work-list.pdf
CrossCheck Report 108520-crosscheck-report.pdf