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Articles Published Processes
8/27/2025 9:21:15 AM | Browse: 119 | Download: 168
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Received |
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2025-04-17 11:16 |
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Peer-Review Started |
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2025-04-27 00:12 |
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To Make the First Decision |
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Return for Revision |
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2025-06-05 09:29 |
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Revised |
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2025-06-16 17:47 |
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Second Decision |
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2025-07-24 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-24 08:27 |
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Articles in Press |
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2025-07-24 08:27 |
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Publication Fee Transferred |
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2025-06-20 07:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-15 03:14 |
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Publish the Manuscript Online |
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2025-08-27 09:21 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Meta-Analysis |
| Article Title |
Response rates, survival status and adverse events of placebo in randomized control trials for hepatocellular carcinoma: A meta-analysis
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei-Yu Chen, Qing Chen, Chen-Chen Wang, Chen-Yue Zhang, Si-Kun Chen, Zhi-Qiang Meng, Ping Han, Shu Dong and Qi-Wen Chen |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Qi-Wen Chen, MD, Department of Integrative Oncology, Fudan University Shanghai Cancer Center, No. 270 Dongan Road, Shanghai 200032, China. cqwly@hotmail.com |
| Key Words |
Hepatocellular carcinoma; Placebo; Randomized controlled trials; Response rates; Survival status; Adverse events |
| Core Tip |
While the therapeutic arm dominates hepatocellular carcinoma clinical trials, the placebo comparator serves as a critical but underutilized window into tumor biology. The natural course of hepatocellular carcinoma under placebo conditions remains poorly quantified, masking potential spontaneous stabilization mechanisms. Furthermore, placebo-associated adverse events in randomized controlled trials remain poorly characterized. Our meta-analysis addresses these gaps through systematically evaluated response rates, survival status and adverse events across placebo arms of hepatocellular carcinoma randomized controlled trials. |
| Publish Date |
2025-08-27 09:21 |
| Citation |
<p>Chen WY, Chen Q, Wang CC, Zhang CY, Chen SK, Meng ZQ, Han P, Dong S, Chen QW. Response rates, survival status and adverse events of placebo in randomized control trials for hepatocellular carcinoma: A meta-analysis. <i>World J Hepatol</i> 2025; 17(8): 108533</p> |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i8/108533.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i8.108533 |
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