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Articles Published Processes
9/17/2025 8:57:36 AM | Browse: 434 | Download: 33
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Received |
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2025-04-17 02:55 |
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Peer-Review Started |
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2025-04-17 02:56 |
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To Make the First Decision |
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Return for Revision |
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2025-05-15 08:45 |
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Revised |
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2025-05-29 08:35 |
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Second Decision |
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2025-07-14 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-15 08:07 |
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Articles in Press |
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2025-07-15 08:07 |
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Publication Fee Transferred |
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2025-06-04 13:24 |
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Edit the Manuscript by Language Editor |
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2025-07-21 22:28 |
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Typeset the Manuscript |
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2025-08-29 02:54 |
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Publish the Manuscript Online |
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2025-09-17 08:57 |
| ISSN |
2220-6124 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Basic Study |
| Article Title |
Adipose-derived mesenchymal stromal cell secretome protects against kidney injury through induction of heme oxygenase 1 upregulation in vitro
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hanan Jafar, Nidaa A Ababneh, Dana Alhattab, Renata M Alatoom, Suzan Zalloum, Bareqa Salah, Hussein Alhawari and Abdalla Awidi |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Abdul Hameed Shoman Foundation (AHSF) |
6/2018 |
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| Corresponding Author |
Abdalla Awidi, Cell Therapy Center, The University of Jordan, Queen Rania St, Amman 11942, Amman, Jordan. aabbadi@ju.edu.jo |
| Key Words |
Acute kidney injury; Mesenchymal stromal cells; Oxidative stress; HO-1 upregulation; Secretome; Renal tubular epithelial cells |
| Core Tip |
This study highlights the therapeutic potential of secretome derived from adipose-derived mesenchymal stromal cells (ADMSCs) in protecting renal tubular epithelial cells under oxidative stress conditions. The ADMSC secretome reduced reactive oxygen species levels, enhanced mitochondrial membrane potential, and upregulated heme oxygenase-1 gene expression, indicating activation of cytoprotective pathways. Comparative transcriptome analysis with bone marrow-derived mesenchymal stromal cells revealed distinct gene expression profiles related to mitochondrial and antioxidant functions. These findings support the use of ADMSC secretome as a promising cell-free approach for mitigating oxidative damage in acute kidney injury. |
| Publish Date |
2025-09-17 08:57 |
| Citation |
<p>Jafar H, Ababneh NA, Alhattab D, Alatoom RM, Zalloum S, Salah B, Alhawari H, Awidi A. Adipose-derived mesenchymal stromal cell secretome protects against kidney injury through induction of heme oxygenase 1 upregulation in vitro. <i>World J Nephrol</i> 2025; 14(3): 108534</p> |
| URL |
https://www.wjgnet.com/2220-6124/full/v14/i3/108534.htm |
| DOI |
https://dx.doi.org/10.5527/wjn.v14.i3.108534 |
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