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Articles Published Processes
8/14/2025 5:49:36 AM | Browse: 98 | Download: 374
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Received |
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2025-04-17 03:28 |
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Peer-Review Started |
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2025-04-17 03:28 |
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First Decision by Editorial Office Director |
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2025-05-13 12:01 |
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Return for Revision |
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2025-05-13 12:01 |
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Revised |
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2025-05-26 01:47 |
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Publication Fee Transferred |
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2025-05-28 09:06 |
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Second Decision by Editor |
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2025-07-11 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-07-11 09:36 |
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Articles in Press |
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2025-07-11 09:36 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-01 06:26 |
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Publish the Manuscript Online |
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2025-08-14 05:49 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Interleukin-22 promotes cancer stemness and chemotherapy resistance in colorectal cancer via epidermal growth factor receptor/extracellular signal-regulated kinase pathway
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hong-Xun Ruan, Yan-Le Fang, Xiao-Ning Qin and Lin Lin |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Lin Lin, MD, The Third Department of General Surgery, The second Hospital of Hebei Medical University, No. 215 Heping West Road, Shijiazhuang 050004, Hebei Province, China. linlin779242000@163.com |
| Key Words |
Interleukin-22; Colorectal cancer; Oxaliplatin; Epidermal growth factor receptor; Extracellular signal-regulated kinase |
| Core Tip |
This study reveals that interleukin-22 (IL-22) enhances stem cell-like traits and promotes resistance to oxaliplatin in colorectal cancer (CRC) cells. Mechanistically, IL-22 activates the epidermal growth factor receptor (EGFR)/extracellular signal-regulated kinase signaling pathway. Inhibition of EGFR with osimertinib reverses IL-22-induced chemoresistance. These findings highlight IL-22 as a critical mediator of therapeutic resistance and a potential target for overcoming drug resistance in CRC treatment. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
Ruan HX, Fang YL, Qin XN, Lin L. Interleukin-22 promotes cancer stemness and chemotherapy resistance in colorectal cancer via epidermal growth factor receptor/extracellular signal-regulated kinase pathway. World J Gastrointest Oncol 2025; 17(8): 108535 |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/108535.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.108535 |
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