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Articles Published Processes
9/5/2025 6:36:19 AM | Browse: 493 | Download: 336
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Received |
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2025-04-24 13:34 |
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Peer-Review Started |
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2025-04-24 13:34 |
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First Decision by Editorial Office Director |
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2025-05-10 04:32 |
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Return for Revision |
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2025-05-10 04:32 |
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Revised |
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2025-05-22 01:02 |
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Publication Fee Transferred |
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2025-05-27 01:04 |
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Second Decision by Editor |
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2025-08-13 05:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-13 08:19 |
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Articles in Press |
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2025-08-13 08:19 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-02 03:48 |
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Publish the Manuscript Online |
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2025-09-05 06:36 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Dopamine receptor D1-mediated suppression of liver fibrosis via Hippo/Yes-associated protein 1 signaling in levodopa treatment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Yan Wang, Man-Man Qi, Kai Zhang, Yu-Zhao Zhu and Jian Zhang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jian Zhang, PhD, Professor, Department of Nuclear Medicine, Universal Medical Imaging Diagnostic Center, Shanghai University, No. 168 Changhai Road, YangPu District, Shanghai 200233, China. abiaoxp@163.com |
| Key Words |
Levodopa; Liver fibrosis; Yes-associated protein 1 transcriptional regulator; Hippo/Yes-associated protein 1 signaling pathway; Dopamine receptor D1 |
| Core Tip |
This study found that levodopa significantly alleviated CCl4-induced liver fibrosis in rats by upregulating Gα s-coupled protein dopamine receptor D1 (DRD1) expression and enhancing Yes-associated protein 1 (YAP) phosphorylation through the activation of the Hippo signaling pathway. This study for the first time demonstrates levodopa's potential as a novel therapeutic strategy targeting the DRD1-Hippo/YAP axis in liver fibrosis. |
| Publish Date |
2025-09-05 06:36 |
| Citation |
Wang HY, Qi MM, Zhang K, Zhu YZ, Zhang J. Dopamine receptor D1-mediated suppression of liver fibrosis via Hippo/Yes-associated protein 1 signaling in levodopa treatment. World J Gastroenterol 2025; 31(34): 108617 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i34/108617.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i34.108617 |
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