Publication Name	World Journal of Gastrointestinal Oncology
Manuscript ID	108650
Country	China

Received	2025-04-21 05:30
Peer-Review Started	2025-04-21 05:30
To Make the First Decision
Return for Revision	2025-04-28 09:03
Revised	2025-05-19 17:38
Second Decision	2025-06-04 02:36
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-06-04 09:08
Articles in Press	2025-06-04 09:08
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-07-02 00:35
Publish the Manuscript Online	2025-07-14 12:55

ISSN	1948-5204 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Oncology
Manuscript Type	Case Report
Article Title	Pathological complete response in advanced intrahepatic cholangiocarcinoma was achieved through tri-modal therapy: A case report and review of literature
Manuscript Source	Unsolicited Manuscript
All Author List	Ju-Ping Xie, Ya-Jun Tang, You-Wen Fan, Ying-Zi Huang, Min Deng, Tian-Zhi Zhang, You Li, Gang Deng and Di Tang
ORCID	Author(s) ORCID Number Ju-Ping Xie http://orcid.org/0009-0003-7646-4821 Ya-Jun Tang http://orcid.org/0000-0001-6059-0725 Ying-Zi Huang http://orcid.org/0009-0002-0101-2532 Min Deng http://orcid.org/0009-0004-8049-8765 You Li http://orcid.org/0009-0009-6851-1660 Gang Deng http://orcid.org/0000-0002-7409-7138 Di Tang http://orcid.org/0000-0002-6486-273X
Funding Agency and Grant Number
Corresponding Author	Di Tang, Associate Chief Physician, Director, Department of General Surgery, The Seventh Affiliated Hospital, Sun Yat-sen University, No. 628 Zhenyuan Road, Shenzhen 518107, Guangdong Province, China. tangdi@mail.sysu.edu.cn
Key Words	Intrahepatic cholangiocarcinoma; Hepatic arterial infusion chemotherapy; Lenvatinib; Toripalimab; Surgery; Case report
Core Tip	This report details an unresectable advanced intrahepatic cholangiocarcinoma (ICC) patient treated with first-line GEMOX-HAIC, lenvatinib, and toripalimab. This tri-modal therapy led to successful R0 resection and complete pathological remission. The patient achieved 29 months of disease-free survival. This rare case highlights a regimen enabling surgical resection and long-term survival in advanced ICC and discusses multidisciplinary management of severe biliary complications. However, as a single case, generalizability is limited. The regimen's efficacy and safety warrant validation in prospective, multi-center clinical trials.
Publish Date	2025-07-14 12:55
Citation	<p>Xie JP, Tang YJ, Fan YW, Huang YZ, Deng M, Zhang TZ, Li Y, Deng G, Tang D. Pathological complete response in advanced intrahepatic cholangiocarcinoma was achieved through tri-modal therapy: A case report and review of literature. <i>World J Gastrointest Oncol</i> 2025; 17(7): 108650</p>
URL	https://www.wjgnet.com/1948-5204/full/v17/i7/108650.htm
DOI	https://dx.doi.org/10.4251/wjgo.v17.i7.108650

Full Article (PDF)	WJGO-17-108650-with-cover.pdf
CARE Checklist–2016	108650-CARE-Checklist-2016.pdf
Manuscript File	108650_Auto_Edited_060241.docx
Answering Reviewers	108650-answering-reviewers.pdf
Audio Core Tip	108650-audio.MP3
Conflict-of-Interest Disclosure Form	108650-conflict-of-interest-statement.pdf
Copyright License Agreement	108650-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108650-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	108650-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	108650-non-native-speakers.pdf
Peer-review Report	108650-peer-reviews.pdf
Scientific Editor Work List	108650-scientific-editor-work-list.pdf
CrossCheck Report	108650-crosscheck-report.pdf