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Articles Published Processes
8/27/2025 3:44:00 AM | Browse: 44 | Download: 62
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Received |
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2025-06-10 09:15 |
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Peer-Review Started |
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2025-06-10 09:15 |
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To Make the First Decision |
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Return for Revision |
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2025-06-24 08:46 |
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Revised |
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2025-07-10 13:55 |
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Second Decision |
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2025-08-04 02:45 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-04 05:11 |
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Articles in Press |
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2025-08-04 05:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-15 08:23 |
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Publish the Manuscript Online |
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2025-08-27 03:44 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qian Zhao, Hui Zhang, Huang-Min Wu, Qun-Ying Yang, Hong Zhao, Le Kang and Xiang-Yin Lv |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Jinhua Municipal Science and Technology Bureau |
2022-4-254 |
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| Corresponding Author |
Xiang-Yin Lv, Professor, Department of Gastroenterology, Dongyang People’s Hospital, No. 60 Wuning West Road, Dongyang 322100, Zhejiang Province, China. lvxiangyin1982@163.com |
| Key Words |
Melatonin; Pancreatic cancer; Activating transcription factor 4; Alanine-serine-cysteine transporter 2; Ferroptosis |
| Core Tip |
In the present study, we demonstrate that melatonin activates endoplasmic reticulum stress-mediated-ferroptosis in the protein kinase R-like endoplasmic reticulum kinase-eukaryotic initiation factor 2α-activating transcription factor 4 axis via inhibition of the alanine-serine-cysteine transporter 2-glutathione peroxidase 4 signaling pathway, thereby exerting an anti-cancer effect on pancreatic cancer cells. These new findings suggest that melatonin may act as a potent anti-tumor agent and may have great potential as an adjuvant therapy in the future. |
| Publish Date |
2025-08-27 03:44 |
| Citation |
<p>Zhao Q, Zhang H, Wu HM, Yang QY, Zhao H, Kang L, Lv XY. Melatonin-induced ferroptosis in pancreatic cancer cells by stimulating endoplasmic reticulum stress and inhibiting alanine-serine-cysteine transporter 2-driven glutamine metabolism. <i>World J Gastroenterol</i> 2025; 31(32): 108654</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i32/108654.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i32.108654 |
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