| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cell Biology |
| Manuscript Type |
Minireviews |
| Article Title |
Dual role and clinical application of extracellular vesicles in acute respiratory distress syndrome: Mechanism analysis and translational challenges
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Fu Tie, Han Liu, Tong Zhang, Tian-Wei Meng and Qun Liang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82374400 |
| Heilongjiang Province “Double First-Class” New Round of Construction Disciplines Collaborative Innovation Achievements Construction Project |
LJGXCG2022-097 |
|
| Corresponding Author |
Qun Liang, Chief Physician, Full Professor, MD, PhD, Professor, Department of Critical Care Medicine, First Affiliated Hospital of Heilongjiang University of Chinese Medicine, No. 24 Heping Road, Xiangfang District, Harbin 150000, Heilongjiang Province, China. liangqun1@sina.com |
| Key Words |
Acute respiratory distress syndrome; Extracellular vesicles; Biomarkers; Inflammation; Therapeutic strategies |
| Core Tip |
Acute respiratory distress syndrome, a critical illness with a mortality of over 35%, is driven by dysregulated pulmonary inflammation and alveolar injury. Extracellular vesicles (EVs) demonstrate dual regulatory functions - pathogen-derived pro-inflammatory EVs exacerbate macrophage-driven injury, while mesenchymal stem cell EVs suppress inflammation and enhance tissue repair. Current research focuses on EV heterogeneity, spatiotemporal functional dynamics, and clinical translation barriers in therapeutic development. This synthesis integrates mechanistic insights, biomarker advancements, and engineered EV strategies, emphasizing standardization challenges and biosafety considerations. Emerging interdisciplinary approaches, combining multi-omics profiling, nanotechnology, and machine learning, aim to refine EV-based diagnostics and therapeutics, offering transformative potential for acute respiratory distress syndrome management. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
<p>Tie YF, Liu H, Zhang T, Meng TW, Liang Q. Dual role and clinical application of extracellular vesicles in acute respiratory distress syndrome: Mechanism analysis and translational challenges. <i>World J Stem Cells</i> 2025; 17(9): 108657</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/108657.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.108657 |
