| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Immunology |
| Manuscript Type |
Basic Study |
| Article Title |
Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hai-Hang Nie, Xue-Ying Yang, Jing-Kai Zhou, Gui-Lin Gao, Lu Ding, Yun-Tian Hong, Ya-Li Yu, Pei-Shan Qiu, Zi-Yue Zeng, Jun Lai, Ting Zheng, Hai-Zhou Wang, Qiu Zhao and Fan Wang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
82403279 and 82303181 |
|
| Corresponding Author |
Fan Wang, Department of Gastroenterology, Zhongnan Hospital of Wuhan University, No. 169 Donghu Road, Wuhan 430070, Hubei Province, China. 2020283030092@whu.edu.cn |
| Key Words |
Histone deacetylases 10; Colorectal cancer; Tumor microenvironment; Immunotherapy; Prognosis |
| Core Tip |
Histone deacetylases 10 (HDAC10), a HDAC family member, was overexpressed in colorectal cancer (CRC) and associated with poor prognosis. HDAC10 depletion inhibited CRC cell proliferation and migration, suggesting its oncogenic role. Gene set variation analysis linked elevated HDAC10 expression to immunosuppressive pathways and a non-inflamed tumor microenvironment (TME), characterized by reduced immune cell infiltration. CRC patients with high HDAC10 levels showed reduced sensitivity to immunotherapy, indicating therapeutic resistance. Our findings highlight HDAC10’s critical role in shaping the TME, treatment response, and clinical outcomes in CRC, supporting its potential as a therapeutic target to improve CRC management. |
| Publish Date |
2025-07-11 07:47 |
| Citation |
<p>Nie HH, Yang XY, Zhou JK, Gao GL, Ding L, Hong YT, Yu YL, Qiu PS, Zeng ZY, Lai J, Zheng T, Wang HZ, Zhao Q, Wang F. Histone deacetylases 10 as a prognostic biomarker correlates with tumor microenvironment and therapy response in colorectal cancer. <i>World J Gastroenterol</i> 2025; 31(26): 108662</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i26/108662.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i26.108662 |
