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Articles Published Processes
11/21/2025 7:06:15 AM | Browse: 86 | Download: 224
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Received |
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2025-04-20 04:02 |
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Peer-Review Started |
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2025-04-20 04:03 |
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First Decision by Editorial Office Director |
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2025-05-17 07:32 |
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Return for Revision |
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2025-05-17 07:32 |
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Revised |
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2025-06-22 21:48 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-10-09 01:15 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-10-10 02:17 |
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Articles in Press |
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2025-10-10 02:17 |
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Edit the Manuscript by Language Editor |
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2025-10-29 17:29 |
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Typeset the Manuscript |
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2025-11-12 02:27 |
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Publish the Manuscript Online |
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2025-11-21 07:06 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Review |
| Article Title |
Chimeric antigen receptor T cell therapy: Revolutionizing cancer treatment
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Samarah Arjumand, Asef Raj, Kazi Milenur Rahman Prattay, Humair Bin Md Omer and Faruque Azam |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Faruque Azam, Lecturer, Research Fellow, School of Pharmacy, BRAC University, Kha 224, Pragati Sarani, Merul Badda, Dhaka 1212, Bangladesh. faruque.azam@bracu.ac.bd |
| Key Words |
Chimeric antigen receptor; Cancer immunotherapy; T cell engineering; Chimeric antigen receptor structure; Immunotherapy challenges; Chimeric antigen receptor T clinical trials |
| Core Tip |
This review presents a comprehensive and forward-looking analysis of chimeric antigen receptor T (CAR-T) cell therapy, detailing its structural evolution, manufacturing strategies, and cytotoxic mechanisms. It uniquely integrates emerging advancements such as dual CARs, SynNotch systems, and universal CAR-T designs. The manuscript also addresses clinical challenges like antigen escape and cytokine release syndrome, and highlights innovative gene delivery technologies, including viral vectors, CRISPR/Cas9, and RNA-based methods. This work offers a consolidated and insightful resource for researchers and clinicians aiming to advance CAR-T therapy toward safer and more effective cancer treatments. |
| Publish Date |
2025-11-21 07:06 |
| Citation |
Arjumand S, Raj A, Prattay KMR, Omer HBM, Azam F. Chimeric antigen receptor T cell therapy: Revolutionizing cancer treatment. World J Clin Oncol 2025; 16(11): 108667 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i11/108667.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i11.108667 |
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