Publication Name	World Journal of Gastroenterology
Manuscript ID	10869
Country	Italy

Received	2014-04-23 20:34
Peer-Review Started	2014-04-24 20:29
To Make the First Decision	2014-05-29 19:20
Return for Revision	2014-06-05 19:33
Revised	2014-06-17 15:48
Second Decision	2014-08-28 10:00
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief	2014-08-28 10:33
Articles in Press	2014-08-28 10:56
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-25 09:30
Publish the Manuscript Online	2014-12-18 17:08

ISSN	1007-9327 (print) and 2219-2840 (online)
Open Access
Copyright
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Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Letter to the Editor
Article Title	Reversal of IgM deficiency following a gluten-free diet in seronegative celiac disease
Manuscript Source	Unsolicited Manuscript
All Author List	Lucia Montenegro, Domenico Piscitelli, Floriana Giorgio, Claudia Covelli, Maria Grazia Fiore, Giuseppe Losurdo, Andrea Iannone, Enzo Ierardi, Alfredo Di Leo and Mariabeatrice Principi
Funding Agency and Grant Number
Corresponding Author	Alfredo Di Leo, Professor, Gastroenterology Unit, Policlinico Hospital, Piazza G Cesare 11, 70124 Bari, Italy. alfredo.dileo@uniba.it
Key Words	Selective IgM deficiency; Seronegative celiac disease; Tissue transglutaminase; Gluten-free diet
Core Tip	Selective IgM deficiency is a rare condition, associated in 5% of cases to Celiac Disease (CD). The CD diagnosis in patients with immunoglobulin deficiencies is based only on response to a Gluten-Free Diet (GFD). Deposits of tissue transglutaminase are found in duodenal samples of seronegative CD. Our case (IgM deficiency/seronegative CD) disclosed novel insights: (1) it is possible to observe a selective association of IgM deficiency/seronegative CD; (2) the histological diagnosis of CD may be complex due to poor lymphocyte maturation; (3) mRNA coding for tissue transglutaminase in duodenal mucosa could be a useful diagnostic tool; and (4) GFD may reverse IgM deficiency by promoting lymphocyte maturation.
Publish Date	2014-12-18 17:08
Citation	Montenegro L, Piscitelli D, Giorgio F, Covelli C, Fiore MG, Losurdo G, Iannone A, Ierardi E, Di Leo A, Principi M. Reversal of IgM deficiency following a gluten-free diet in seronegative celiac disease. World J Gastroenterol 2014; 20(46): 17686-17689
URL	http://www.wjgnet.com/1007-9327/full/v20/i46/17686.htm
DOI	http://dx.doi.org/10.3748/wjg.v20.i46.17686

Full Article (PDF)	WJG-20-17686.pdf
Full Article (Word)	WJG-20-17686.doc
Manuscript File	10869-Review.doc
Answering Reviewers	10869-Answering reviewers.pdf
Copyright License Agreement	10869-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate	10869-Language certificate.pdf
Peer-review Report	10869-Peer review.pdf
Scientific Misconduct Check	10869-CorssCheck.jpg
Scientific Editor Work List	10869-Scientific editor work list.pdf