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1/20/2015 9:10:00 PM | Browse: 1108 | Download: 1349
Publication Name World Journal of Gastroenterology
Manuscript ID 10871
Country/Territory China
Received
2014-04-23 20:31
Peer-Review Started
2014-04-24 20:22
To Make the First Decision
2014-05-29 19:20
Return for Revision
2014-06-05 19:34
Revised
2014-06-18 21:56
Second Decision
2014-07-16 17:22
Accepted by Journal Editor-in-Chief
Accepted by Company Editor-in-Chief
2014-07-16 17:35
Articles in Press
2014-07-16 17:53
Publication Fee Transferred
Edit the Manuscript by Language Editor
2014-07-27 21:49
Typeset the Manuscript
2015-01-09 08:55
Publish the Manuscript Online
2015-01-20 20:12
ISSN 1007-9327 (print) and 2219-2840 (online)
Open Access This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
Copyright © The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Gastroenterology & Hepatology
Manuscript Type Autobiography
Article Title Hes1, an important gene for the activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling
Manuscript Source Unsolicited Manuscript
All Author List Kai Zhang, Yan-Qiong Zhang, Wen-Bing Ai, Qing-Ting Hu, Qiao-Juan Zhang, Lin-Yan Wan, Xiao-Lian Wang, Chang-Bai Liu and Jiang-Feng Wu
Funding Agency and Grant Number
Funding Agency Grant Number
National Natural Science Foundation of China 81170412
National Natural Science Foundation of China 81070348
National Natural Science Foundation of China 81200307
Health Department of Hubei Province of China JX6C-26
Corresponding Author Jiang-Feng Wu, Professor, Institute of Molecular Biology, Medical College, China Three Gorges University, 8 Daxue Road, Xiling District, Yichang 443002, Hubei Province, China. 313229177@qq.com
Key Words Hes1; Notch1; TGF-β/BMP; Hepatic stellate cells; Hepatic fibrosis
Core Tip In our paper, we found Notch signaling appears to crosstalk with TGF-β/BMP signaling and co-regulate the expression of Hes1 in HSCs. Notch1 may keep Hes1 protein in a reasonable range due to Hes1 auto-negative feedback, allowing Notch1 to repress the expression of α-SMA and COL1α2. Over-expression of Hes1 via transfection, thus lacking the negative feedback, enhances the promoter activity of α-SMA and COL1α2, consistent with the finding when Hes1 is captured by a Hes1-decoy ODN. This may provide an anti-fibrotic strategy for hepatic fibrosis. Further investigation in the future on the molecular mechanism of Hes1 regulating the expression of the α-SMA, COL1α2 should provide additional support for such an approach.
Publish Date 2015-01-20 20:12
Citation Zhang K, Zhang YQ, Ai WB, Hu QT, Zhang QJ, Wan LY, Wang XL, Liu CB, Wu JF. Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling. World J Gastroenterol 2015; 21(3): 878-887
URL http://www.wjgnet.com/1007-9327/full/v21/i3/878.htm
DOI http://dx.doi.org/10.3748/wjg.v21.i3.878
Full Article (PDF) WJG-21-878.pdf
Full Article (Word) WJG-21-878.doc
Manuscript File 10871-Review.doc
Answering Reviewers 10871-Answering reviewers.pdf
Copyright License Agreement 10871-Copyright assignment.pdf
Non-Native Speakers of English Editing Certificate 10871-Language certificate.pdf
Peer-review Report 10871-Peer review.pdf
Scientific Misconduct Check 10871-CorssCheck.jpg
Scientific Editor Work List 10871-Scientific editor work list.pdf