ISSN |
1007-9327 (print) and 2219-2840 (online) |
Open Access |
This article is an open-access article which was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
Copyright |
© The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
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Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
Website |
http://www.wjgnet.com |
Category |
Gastroenterology & Hepatology |
Manuscript Type |
Autobiography |
Article Title |
Hes1, an important gene for the activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling
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Manuscript Source |
Unsolicited Manuscript |
All Author List |
Kai Zhang, Yan-Qiong Zhang, Wen-Bing Ai, Qing-Ting Hu, Qiao-Juan Zhang, Lin-Yan Wan, Xiao-Lian Wang, Chang-Bai Liu and Jiang-Feng Wu |
Funding Agency and Grant Number |
Funding Agency |
Grant Number |
National Natural Science Foundation of China |
81170412 |
National Natural Science Foundation of China |
81070348 |
National Natural Science Foundation of China |
81200307 |
Health Department of Hubei Province of China |
JX6C-26 |
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Corresponding Author |
Jiang-Feng Wu, Professor, Institute of Molecular Biology, Medical College, China Three Gorges University, 8 Daxue Road, Xiling District, Yichang 443002, Hubei Province, China. 313229177@qq.com |
Key Words |
Hes1; Notch1; TGF-β/BMP; Hepatic stellate cells; Hepatic fibrosis |
Core Tip |
In our paper, we found Notch signaling appears to crosstalk with TGF-β/BMP signaling and co-regulate the expression of Hes1 in HSCs. Notch1 may keep Hes1 protein in a reasonable range due to Hes1 auto-negative feedback, allowing Notch1 to repress the expression of α-SMA and COL1α2. Over-expression of Hes1 via transfection, thus lacking the negative feedback, enhances the promoter activity of α-SMA and COL1α2, consistent with the finding when Hes1 is captured by a Hes1-decoy ODN. This may provide an anti-fibrotic strategy for hepatic fibrosis. Further investigation in the future on the molecular mechanism of Hes1 regulating the expression of the α-SMA, COL1α2 should provide additional support for such an approach. |
Publish Date |
2015-01-20 20:12 |
Citation |
Zhang K, Zhang YQ, Ai WB, Hu QT, Zhang QJ, Wan LY, Wang XL, Liu CB, Wu JF. Hes1, an important gene for activation of hepatic stellate cells, is regulated by Notch1 and TGF-β/BMP signaling. World J Gastroenterol 2015; 21(3): 878-887 |
URL |
http://www.wjgnet.com/1007-9327/full/v21/i3/878.htm |
DOI |
http://dx.doi.org/10.3748/wjg.v21.i3.878 |