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Articles Published Processes
9/23/2025 6:48:59 AM | Browse: 57 | Download: 70
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Received |
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2025-04-29 05:24 |
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Peer-Review Started |
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2025-04-29 05:24 |
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To Make the First Decision |
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Return for Revision |
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2025-05-17 07:38 |
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Revised |
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2025-06-16 16:56 |
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Second Decision |
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2025-08-11 02:51 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-12 09:54 |
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Articles in Press |
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2025-08-12 09:54 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-11 00:58 |
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Publish the Manuscript Online |
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2025-09-23 06:48 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pharmacology & Pharmacy |
| Manuscript Type |
Review |
| Article Title |
Responsive mesoporous silica nanocarriers in glioma therapy: A step forward in overcoming biological barriers
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yasmeen Tarek Abdel-Maksoud, Ahmed Helmy Abdelhaseb, Amr Abd-Elraheem Abdo, Ahmed Mohamed Kamel, Mohamed Tallat Elsebay and Mohamed Salah Attia |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mohamed Salah Attia, Department of Pharmaceutics, Faculty of Pharmacy, Zagazig University, University Street, Shaibet an Nakareyah, Zagazig 44519, Al-Sharqia Governorate, Egypt. mosalahnabet@gmail.com |
| Key Words |
Glioblastoma multiforme; Mesoporous silica nanoparticles; Blood-brain barrier; Stimuli-responsive drug delivery; Targeted nanocarriers; Tumor microenvironment |
| Core Tip |
Mesoporous silica nanoparticles (MSNs) offer a promising solution for glioma treatment due to their large surface area, tunable pore sizes, and high drug-loading capacity. By functionalizing their surfaces with tumor-specific ligands, MSNs enhance targeted uptake by glioma cells, minimizing off-target toxicity. They can also respond to both endogenous (e.g., acidic pH, redox conditions) and exogenous (e.g., magnetic fields, ultrasound) stimuli for controlled, localized drug release. These properties enable MSNs to overcome blood-brain barrier challenges and improve treatment outcomes while reducing side effects. |
| Publish Date |
2025-09-23 06:48 |
| Citation |
<p>Abdel-Maksoud YT, Abdelhaseb AH, Abdo AAE, Kamel AM, Elsebay MT, Attia MS. Responsive mesoporous silica nanocarriers in glioma therapy: A step forward in overcoming biological barriers. <i>World J Clin Oncol</i> 2025; 16(9): 108731</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i9/108731.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i9.108731 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
