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Articles Published Processes
9/25/2025 9:22:05 AM | Browse: 61 | Download: 12
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Received |
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2025-04-22 13:16 |
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Peer-Review Started |
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2025-04-22 13:17 |
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To Make the First Decision |
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Return for Revision |
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2025-05-30 03:41 |
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Revised |
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2025-06-10 22:15 |
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Second Decision |
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2025-08-27 02:39 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-27 10:24 |
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Articles in Press |
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2025-08-27 10:24 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-08-30 18:17 |
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Typeset the Manuscript |
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2025-09-11 01:59 |
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Publish the Manuscript Online |
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2025-09-25 09:22 |
| ISSN |
2220-3249 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Cardiac & Cardiovascular Systems |
| Manuscript Type |
Systematic Reviews |
| Article Title |
Hepatitis C virus-associated cardiomyopathy: A review of pathogenesis
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Inderjeet Singh Bharaj, Gurkaranvir Singh, Ajit Singh Brar, Aayushi Kacheria, Jasraj Kahlon, Billal Mohmand, Aalam Sohal and Beeletsega T Yeneneh |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Aalam Sohal, Department of Gastroenterology and Hepatology, Creighton University School of Medicine, 3216 NE 45th Pl Suite 212, Phoenix, AZ 85012, United States. aalamsohal@gmail.com |
| Key Words |
Hepatitis C virus; Cardiomyopathy; Direct-acting antivirals; Cirrhosis; Cardiotropic |
| Core Tip |
Chronic hepatitis C virus (HCV) infection is emerging as a significant contributor to cardiomyopathy, including dilated, hypertrophic, and arrhythmogenic subtypes. This review synthesizes evidence outlining complex pathogenic mechanisms: Direct viral toxicity via HCV core protein–mediated cytokine release (e.g., tumor necrosis factor alpha), immune-mediated damage, genetic predispositions, apoptotic pathways, and cirrhotic cardiomyopathy from HCV-induced liver disease. Notably, direct-acting antiviral (DAA) therapies not only achieve high cure rates but also improve cardiac function, although potential cardiotoxic effects require vigilance. The study underscores the need for further research into mechanistic insights, biomarker validation, and expanding global DAA access to mitigate cardiovascular risks to improve patient outcomes. |
| Publish Date |
2025-09-25 09:22 |
| Citation |
<p>Bharaj IS, Singh G, Brar AS, Kacheria A, Kahlon J, Mohmand B, Sohal A, Yeneneh BT. Hepatitis C virus-associated cardiomyopathy: A review of pathogenesis. <i>World J Virol</i> 2025; 14(3): 108754</p> |
| URL |
https://www.wjgnet.com/2220-3249/full/v14/i3/108754.htm |
| DOI |
https://dx.doi.org/10.5501/wjv.v14.i3.108754 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
