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Articles Published Processes
9/15/2025 8:37:56 AM | Browse: 155 | Download: 47
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Received |
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2025-04-24 13:32 |
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Peer-Review Started |
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2025-04-24 13:33 |
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To Make the First Decision |
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Return for Revision |
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2025-05-22 00:24 |
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Revised |
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2025-06-13 03:03 |
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Second Decision |
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2025-07-22 02:40 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-22 03:50 |
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Articles in Press |
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2025-07-22 03:50 |
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Publication Fee Transferred |
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2025-06-19 06:21 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-01 08:24 |
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Publish the Manuscript Online |
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2025-09-15 08:37 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Basic Study |
| Article Title |
Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yi-Jia Chen, Cheng Peng, Li-Wei Wang, Jia-Xin Chai, Jian-Dong Wang and Qi-Bin He |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Nanjing Health Science and Technology Development Fund |
YKK24223 |
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| Corresponding Author |
Qi-Bin He, Director, Professor, Gastroenterology, the Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing 211100, China, <label>*</label>Correspondence: <email>13770936117@163.com</email> (Q.H.); <email>minxue.zheng@sibet.ac.cn</email> (M.Z.), Nanjing 211100, Jiangsu Province, China. 13770936117@163.com |
| Key Words |
Uncoupling protein 1; Gastric cancer; Hypermethylation; Rap1 signaling |
| Core Tip |
Uncoupling protein 1 (UCP1) plays a significant role in regulating energy expenditure and metabolic homeostasis in brown and beige adipocytes. Hypermethylation of UCP1 was confirmed in gastric cancer (GC) cells and tumor tissues. Overexpression of UCP1 suppressed GC cell proliferation, migration, and invasion, and it promoted apoptosis in vitro. Overexpression of UCP1 also suppressed GC tumor growth in vivo. The level of active Rap1 protein in GC cells was significantly decreased with UCP1 overexpression and significantly increased after UCP1 knockdown. UCP1 plays a role as a tumor suppressor in GC; it regulates Rap1 signaling and may be a potential therapeutic target in GC. |
| Publish Date |
2025-09-15 08:37 |
| Citation |
<p>Chen YJ, Peng C, Wang LW, Chai JX, Wang JD, He QB. Downregulation of uncoupling protein 1 by hypermethylation in gastric cancer activates Rap1 signaling. <i>World J Gastrointest Oncol</i> 2025; 17(9): 108760</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i9/108760.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i9.108760 |
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