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Articles Published Processes
9/26/2025 8:19:30 AM | Browse: 113 | Download: 1
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Received |
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2025-04-23 13:07 |
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Peer-Review Started |
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2025-04-24 06:18 |
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To Make the First Decision |
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Return for Revision |
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2025-05-22 10:01 |
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Revised |
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2025-06-04 06:03 |
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Second Decision |
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2025-07-11 10:44 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-18 10:28 |
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Articles in Press |
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2025-07-18 10:28 |
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Publication Fee Transferred |
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2025-06-17 03:50 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-06 14:51 |
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Publish the Manuscript Online |
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2025-09-26 08:19 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Genetics & Heredity |
| Manuscript Type |
Case Control Study |
| Article Title |
Association of folate metabolism gene polymorphisms with autism susceptibility and symptom severity in the Chinese population
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Cai-Yun Zhang, Yan-Lin Chen, Fang Hou, Yan-Zhi Li, Wan-Xin Wang, Lan Guo, Cai-Xia Zhang, Li Li and Ci-Yong Lu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Key Research and Development Program of China |
No. 2024YFC2707801 |
| Science and Technology Innovation Commission of Shenzhen |
No. JCYJ20230807143800002 |
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| Corresponding Author |
Ci-Yong Lu, MD, PhD, Professor, Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-Sen University, No. 74 Zhongshan Road 2, Guangzhou 510080, Guangdong Province, China. luciyong@mail.sysu.edu.cn |
| Key Words |
Autism spectrum disorder; Folate metabolism; Gene polymorphism; Susceptibility; Severi |
| Core Tip |
This study screened high-frequency and potentially deleterious polymorphisms in folate metabolism-related genes among children with autism spectrum disorder (ASD) using whole-exome sequencing and explored their associations with ASD through a case-control study. The study found that specific folate metabolism gene polymorphisms were significantly associated with both ASD susceptibility and symptom severity. These findings highlight the critical role of the folate metabolism pathway in the pathogenesis of ASD and provide potential molecular targets for early risk assessment and personalized nutritional intervention strategies. |
| Publish Date |
2025-09-26 08:19 |
| Citation |
<p>Zhang CY, Chen YL, Hou F, Li YZ, Wang WX, Guo L, Zhang CX, Li L, Lu CY. Association of folate metabolism gene polymorphisms with autism susceptibility and symptom severity in the Chinese population. <i>World J Psychiatry</i> 2025; 15(10): 108776</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i10/108776.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i10.108776 |
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