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Articles Published Processes
11/19/2025 5:57:47 AM | Browse: 19 | Download: 20
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Received |
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2025-04-24 05:27 |
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Peer-Review Started |
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2025-04-24 05:27 |
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First Decision by Editorial Office Director |
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2025-05-09 13:14 |
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Return for Revision |
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2025-05-09 13:14 |
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Revised |
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2025-05-12 16:42 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-07-25 02:42 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-07-25 08:53 |
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Articles in Press |
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2025-07-25 08:53 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-21 06:14 |
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Publish the Manuscript Online |
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2025-11-19 05:57 |
| ISSN |
2220-3230 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Transplantation |
| Manuscript Type |
Minireviews |
| Article Title |
Critical role of complement in antibody mediated rejection in kidney transplantation
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Khawar Abbas, Muhammed Mubarak, Wajiha Musharraf, Tahir Aziz and Mirza Naqi Zafar |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Khawar Abbas, Professor, Department of Transplant Immunology, Sindh Institute of Urology and Transplantation, Chand Bibi Road, Karachi 74200, Sind, Pakistan. drkhawar_imuno@yahoo.com |
| Key Words |
Complement; Donor-specific antibodies; Kidney; Allograft; Rejection; Graft failure |
| Core Tip |
Antibody-mediated rejection (AMR) is a significant barrier to successful kidney transplantation, driven primarily by donor-specific alloantibodies. These antibodies activate complement pathways within the transplanted kidney, leading to severe inflammatory responses, endothelial injury, and tissue damage. Understanding the complement system’s critical role in AMR has led to innovative therapies aimed at inhibiting complement activation. Such complement-targeted strategies show potential in reducing inflammation, preventing graft injury, and improving overall graft survival. This review highlights the central contribution of complement activation in AMR, emphasizing therapeutic advancements and the importance of complement inhibition as a promising approach for preventing and managing rejection. |
| Publish Date |
2025-11-19 05:57 |
| Citation |
Abbas K, Mubarak M, Musharraf W, Aziz T, Zafar MN. Critical role of complement in antibody mediated rejection in kidney transplantation. World J Transplant 2025; 15(4): 108806 |
| URL |
https://www.wjgnet.com/2220-3230/full/v15/i4/108806.htm |
| DOI |
https://dx.doi.org/10.5500/wjt.v15.i4.108806 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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