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Articles Published Processes
10/27/2025 10:57:49 AM | Browse: 97 | Download: 125
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Received |
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2025-04-24 05:53 |
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Peer-Review Started |
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2025-04-25 00:03 |
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First Decision by Editorial Office Director |
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2025-05-14 09:32 |
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Return for Revision |
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2025-05-14 09:32 |
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Revised |
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2025-06-17 13:36 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-08-25 03:52 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-25 06:32 |
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Articles in Press |
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2025-08-25 06:32 |
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Edit the Manuscript by Language Editor |
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2025-09-02 19:22 |
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Typeset the Manuscript |
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2025-10-17 06:10 |
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Publish the Manuscript Online |
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2025-10-27 10:57 |
| ISSN |
1948-5182 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Nanoparticle-based systems for liver therapy: Overcoming fibrosis and enhancing drug efficacy
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Maria Giovanna Armillotta, Lara Lizzi and Mara Massimi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Mara Massimi, Associate Professor, PhD, Department of Life, Health and Environmental Sciences, University of L'Aquila, Via Vetoio, L'Aquila 67100, Italy. mara.massimi@univaq.it |
| Key Words |
Liver-specific therapies; Liver fibrosis; Liver cirrhosis; Hepatocellular carcinoma; Nanoparticles; Nanocarriers; Ultrasound-guided delivery; Gene delivery |
| Core Tip |
Liver diseases, including fibrosis and hepatocellular carcinoma, represent major global health challenges with limited treatment options, partly due to drug delivery barriers. Therapeutic efficacy is hindered by factors such as portal hypertension, vascular alterations, and particularly the fibrotic microenvironment. This review summarizes the latest advances in nanoparticle-based delivery strategies targeting liver fibrosis, focusing on lipid-based, polymeric, and inorganic nanoparticles (NPs). It also explores emerging combinatorial technologies including gene delivery platforms and ultrasound-assisted microbubble systems. Finally, it briefly integrates toxicity issues, translational considerations and artificial intelligence-guided NPs to provide a comprehensive yet focused overview of promising therapeutic avenues. |
| Publish Date |
2025-10-27 10:57 |
| Citation |
Armillotta MG, Lizzi L, Massimi M. Nanoparticle-based systems for liver therapy: Overcoming fibrosis and enhancing drug efficacy. World J Hepatol 2025; 17(10): 108810 |
| URL |
https://www.wjgnet.com/1948-5182/full/v17/i10/108810.htm |
| DOI |
https://dx.doi.org/10.4254/wjh.v17.i10.108810 |
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