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Articles Published Processes
7/11/2025 7:47:41 AM | Browse: 27 | Download: 122
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Received |
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2025-04-24 11:47 |
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Peer-Review Started |
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2025-04-24 11:48 |
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To Make the First Decision |
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Return for Revision |
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2025-05-30 18:29 |
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Revised |
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2025-06-06 08:10 |
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Second Decision |
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2025-06-26 02:36 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-26 06:42 |
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Articles in Press |
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2025-06-26 06:42 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-07 06:20 |
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Publish the Manuscript Online |
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2025-07-11 07:47 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Metabolic dysfunction-associated steatotic liver disease: Mechanisms, metabolic reprogramming, and therapeutic insights
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wan-Qi Yang, Ling-Ling Xue and Jing-Lin Wang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jing-Lin Wang, PhD, Researcher, Division of Hepatobiliary and Transplantation Surgery, Department of General Surgery, Nanjing Drum Tower Hospital, Clinical College of Nanjing University of Chinese Medicine, No. 321 Zhongshan Road, Nanjing 210008, Jiangsu Province, China. cw20120817@163.com |
| Key Words |
Metabolic dysfunction-associated steatotic liver disease; Aging; Vitamin D receptor; Metabolic reprogramming; Ferroptosis |
| Core Tip |
Metabolic dysfunction-associated steatotic liver disease (MASLD) is a progressive disorder intricately linked to aging through shared pathological pathways. The core mechanism driving aging-aggravated MASLD involves vitamin D receptor (VDR) dysregulation, which amplifies hepatic lipotoxicity by disrupting lipid metabolism and inducing ferroptosis. Although metabolic reprogramming initially serves as an adaptive response to stress, its dysregulation in aging accelerates inflammation and fibrosis. However, precisely targeting the VDR–p53 axis to modulate mitochondrial function and ferroptotic susceptibility, while balancing metabolic adaptation and cell death, remains a critical therapeutic challenge for halting disease progression. |
| Publish Date |
2025-07-11 07:47 |
| Citation |
<p>Yang WQ, Xue LL, Wang JL. Metabolic dysfunction-associated steatotic liver disease: Mechanisms, metabolic reprogramming, and therapeutic insights. <i>World J Gastroenterol</i> 2025; 31(26): 108814</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i26/108814.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i26.108814 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
