BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
6/12/2025 3:45:50 AM | Browse: 101 | Download: 474
 |
Received |
|
2025-04-27 15:09 |
|
Peer-Review Started |
|
2025-04-27 15:09 |
|
First Decision by Editorial Office Director |
|
2025-05-01 02:08 |
|
Return for Revision |
|
2025-05-01 02:08 |
|
Revised |
|
2025-05-10 04:53 |
|
Publication Fee Transferred |
|
2025-05-12 08:06 |
|
Second Decision by Editor |
|
2025-05-26 02:37 |
 |
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-05-26 05:43 |
|
Articles in Press |
|
2025-05-26 05:43 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-06-07 01:06 |
|
Publish the Manuscript Online |
|
2025-06-12 03:45 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Intermittent fasting exacerbates colon inflammation by promoting Th17 cell differentiation through inhibition of gut microbiota-derived indoleacrylic acid
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Rui Fu, Peng Zhang, Jia-Wei Zhang, Yuan Hong, Bo Chen and Guo-Dong Cao |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Anhui University Research Project |
No. 2022AH051171 |
| Natural Science Foundation Project of Anhui Province |
No. 2408085QH271 |
| Anhui Medical University Scientific Research Level Improvement Plan |
No. 2022xkjT028 |
| Health Research Project of Anhui Province |
No. AHWJ2023A30047 |
| Anhui Provincial Natural Science Foundation |
No. 2208085MH240 |
| Scientific Research Project of Anhui Provincial Department of Education |
No. 2022AH051167 |
| Anhui Quality Engineering Project |
No. 2023sx200 |
| Anhui Quality Engineering Project |
No. 2023jyjxggyjY087 |
| Anhui Quality Engineering Project |
No. 2023zyxwjxalk046 |
| Anhui Provincial Postgraduate Education Quality Project |
No. 2024cxcysj062 |
| Anhui Medical University Graduate Research and Practice Innovation Project |
No. YJS20240095 |
|
| Corresponding Author |
Guo-Dong Cao, Full Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230022, Anhui Province, China. 11718242@zju.edu.cn |
| Key Words |
Intermittent fasting; Colon inflammation; Th17 cell; Gut microbiota; Metabolomics |
| Core Tip |
This study demonstrates that long-term intermittent fasting (IF) compromises intestinal barrier function, alters the metabolite profile (reducing anti-inflammatory compounds and increasing pro-inflammatory ones), and induces dysbiosis (increasing pathogenic bacteria while decreasing short-chain fatty acid-producing bacteria), which collectively promote Th17-driven inflammation. Exogenous indoleacrylic acid supplementation restores barrier integrity, suppresses Th17 activation, and enhances interleukin-10 expression, highlighting its therapeutic promise and emphasizing the need for a reevaluation of the long-term safety of IF due to its potential gut-disrupting effects. |
| Publish Date |
2025-06-12 03:45 |
| Citation |
Fu R, Zhang P, Zhang JW, Hong Y, Chen B, Cao GD. Intermittent fasting exacerbates colon inflammation by promoting Th17 cell differentiation through inhibition of gut microbiota-derived indoleacrylic acid. World J Gastroenterol 2025; 31(22): 108815 |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i22/108815.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i22.108815 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
