| ISSN |
2220-3141(online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Critical Care Medicine |
| Manuscript Type |
Minireviews |
| Article Title |
Management of acute liver failure-an updated literature review
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Vignesh K Nagesh, Emelyn Martinez, Shruthi Badam, Jevon Lamar Harrison, Marina Basta, Vivek Joseph Varughese, Ghulam R Anwar, Vishal Deshpande, Deepa Francis, Damien Islek, Sai Priyanka Pulipaka, Ruchi Bhuju, Pratiksha Moliya, Bilal Niazi and Sameh Elias |
| ORCID |
|
| Funding Agency and Grant Number |
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| Corresponding Author |
Vignesh K Nagesh, Department of Internal Medicine, Hackensack Meridian Health Palisades Medical Center, 7600 River Road, North Bergen, NJ 07047, United States. vgneshkrishnan@gmail.com |
| Key Words |
Multidisciplinary management; Liver transplantation; Extracorporeal liver support; N-acetylcysteine; Model for End-Stage Liver Disease score; King’s College Criteria; Drug-induced liver injury; Coagulopathy; Hepatic encephalopathy; Acute liver failure |
| Core Tip |
Acute liver failure (ALF) is a rapidly progressive and life-threatening condition that demands urgent recognition and intervention. This review highlights the latest insights into ALF’s diverse causes, diagnostic strategies, and management approaches. Emphasis is placed on early etiology identification, use of prognostic tools like King’s College Criteria and Model for End-Stage Liver Disease score, and timely initiation of targeted therapies. Advances in liver support systems and transplant accessibility have improved outcomes, yet ALF remains a critical challenge. A multidisciplinary, evidence-based approach is essential to optimize care and explore emerging treatments that may transform the future of ALF management. |
| Publish Date |
2025-11-28 14:00 |
| Citation |
Nagesh VK, Martinez E, Badam S, Harrison JL, Basta M, Varughese VJ, Anwar GR, Deshpande V, Francis D, Islek D, Pulipaka SP, Bhuju R, Moliya P, Niazi B, Elias S. Management of acute liver failure-an updated literature review. World J Crit Care Med 2025; 14(4): 108840 |
| URL |
https://www.wjgnet.com/2220-3141/full/v14/i4/108840.htm |
| DOI |
https://dx.doi.org/10.5492/wjccm.v14.i4.108840 |
