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Articles Published Processes
11/27/2025 9:20:10 AM | Browse: 14 | Download: 96
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Received |
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2025-07-01 08:55 |
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Peer-Review Started |
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2025-07-01 08:55 |
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First Decision by Editorial Office Director |
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2025-07-23 06:37 |
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Return for Revision |
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2025-07-23 06:37 |
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Revised |
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2025-08-06 09:39 |
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Publication Fee Transferred |
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2025-08-07 03:41 |
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Second Decision by Editor |
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2025-09-19 02:40 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-19 07:45 |
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Articles in Press |
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2025-09-19 07:45 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-11-18 00:28 |
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Publish the Manuscript Online |
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2025-11-27 09:20 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Psychology |
| Manuscript Type |
Basic Study |
| Article Title |
Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Ru-Ting Li, Bi-Juan Lan, Zhuo-Yang Xiao, Qing-Huan Shi, Xin-Yi Chen and Feng Li |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| the Beijing Natural Science Foundation |
7232289 |
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| Corresponding Author |
Feng Li, PhD, School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No.11 North Third Ring East Road, Chaoyang District, Beijing 102488, China. lifeng_bucm0610@126.com |
| Key Words |
Sini-Suanzaoren decoction; MT-SIRT1-mediated; Mitochondrial biogenesis; Insomnia rats |
| Core Tip |
This study pioneers the scientific validation of Sini-Suanzaoren decoction (SNSZRD) for insomnia by bridging traditional Chinese medicine (TCM) theory with mitochondrial pathophysiology. We identify 8 blood-brain barrier-penetrating components (e.g., senkyunolide G) that activate the MT-SIRT1 pathway, reversing neuronal mitochondrial dysfunction via dose-dependent upregulation of PPARγ coactivator-1α/nuclear respiratory factor-1/mitochondrial transcription factor A. Crucially, we decode TCM principles: "Soothing liver depression" corresponds to SIRT1 stabilization, while "nourishing heart-spirit" aligns with ATP-dependent synaptic repair. This work establishes SNSZRD as a multi-target mitochondrial regulator, offering novel biomarkers (hypothalamic ATP) and lead compounds for insomnia therapeutics. |
| Publish Date |
2025-11-27 09:20 |
| Citation |
Li RT, Lan BJ, Xiao ZY, Shi QH, Chen XY, Li F. Sini-Suanzaoren decoction regulates mitochondrial biogenesis mediated by MT-SIRT1 in the treatment of insomnia rats. World J Psychiatry 2025; 15(12): 108867 |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i12/108867.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i12.108867 |
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