Publication Name	World Journal of Clinical Pediatrics
Manuscript ID	108878
Country	Russia

Received	2025-04-24 13:52
Peer-Review Started	2025-04-24 13:52
To Make the First Decision
Return for Revision	2025-05-07 01:49
Revised	2025-05-11 17:45
Second Decision	2025-08-12 02:58
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-08-12 09:32
Articles in Press	2025-08-12 09:32
Publication Fee Transferred
Edit the Manuscript by Language Editor	2025-08-16 20:41
Typeset the Manuscript	2025-10-20 02:52
Publish the Manuscript Online	2025-10-31 15:02

ISSN	2219-2808 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Prospective Study
Article Title	Juvenile arthritis damage index predicts poor response to biological treatment: A prospective cohort study
Manuscript Source	Invited Manuscript
All Author List	Zarina A Kolkhidova, Irina P Nikishina, Svetlana I Glukhova, Oleg G Melikhov and Mikhail M Kostik
ORCID	Author(s) ORCID Number Zarina A Kolkhidova http://orcid.org/0000-0002-1935-8585 Irina P Nikishina http://orcid.org/0000-0003-1842-0348 Svetlana I Glukhova http://orcid.org/0000-0002-4285-0869 Oleg G Melikhov http://orcid.org/0000-0001-9442-7707 Mikhail M Kostik http://orcid.org/0000-0002-1180-8086
Funding Agency and Grant Number	Funding Agency Grant Number an independent grant from Pfizer
Corresponding Author	Mikhail M Kostik, MD, PhD, Professor, Hospital Pediatry, Saint-Petersburg State Pediatric Medical University, Lytovskaya 2, Saint Petersburg 194100, Sankt-Peterburg, Russia. kost-mikhail@yandex.ru
Key Words	Juvenile idiopathic arthritis; Juvenile arthritis damage index; Biologic disease-modified antirheumatic drugs; Joint contractures; Treatment response prediction; Pediatric rheumatology
Core Tip	This prospective study biological-naïve juvenile idiopathic arthritis patients demonstrates that baseline articular/extraarticular damage (assessed via the juvenile arthritis damage index) predicts reduced response to biological disease-modifying antirheumatic drugs. Patients with baseline damage demonstrated higher disease activity (polyarticular course, elevated juvenile arthritis disease activity score 71, magnetic resonance imaging erosions) than those without damage. The observed juvenile arthritis damage index reduction in juvenile idiopathic arthritis patients showed significant associations with baseline joint damage status, treatment stability, and absence of uveitis/osteonecrosis. This index encourages early biologic intervention and tailoring personalized treatment strategies to minimize long-term disability and enhance clinical outcomes.
Publish Date	2025-10-31 15:02
Citation	<p>Kolkhidova ZA, Nikishina IP, Glukhova SI, Melikhov OG, Kostik MM. Juvenile arthritis damage index predicts poor response to biological treatment: A prospective cohort study. <i>World J Clin Pediatr</i> 2025; 14(4): 108878</p>
URL	https://www.wjgnet.com/2219-2808/full/v14/i4/108878.htm
DOI	https://dx.doi.org/10.5409/wjcp.v14.i4.108878

Full Article (PDF)	WJCP-14-108878-with-cover.pdf
CONSORT 2010 Statement	108878-CONSORT-2010-statement.pdf
Manuscript File	108878_Auto_Edited_032250.docx
Answering Reviewers	108878-answering-reviewers.pdf
Audio Core Tip	108878-audio.m4a
Biostatistics Review Certificate	108878-biostatistics-statement.pdf
Clinical Trial Registration Statement	108878-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	108878-conflict-of-interest-statement.pdf
Copyright License Agreement	108878-copyright-assignment.pdf
Signed Informed Consent Form(s) or Document(s)	108878-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	108878-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	108878-non-native-speakers.pdf
Supplementary Material	108878-supplementary-material.pdf
Peer-review Report	108878-peer-reviews.pdf
Scientific Misconduct Check	108878-scientific-misconduct-check.png
Scientific Editor Work List	108878-scientific-editor-work-list.pdf
CrossCheck Report	108878-crosscheck-report.pdf