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Articles Published Processes
8/14/2025 5:49:33 AM | Browse: 10 | Download: 12
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Received |
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2025-04-28 11:39 |
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Peer-Review Started |
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2025-04-28 11:39 |
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To Make the First Decision |
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Return for Revision |
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2025-05-15 12:18 |
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Revised |
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2025-05-27 02:24 |
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Second Decision |
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2025-07-01 02:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-01 07:24 |
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Articles in Press |
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2025-07-01 07:24 |
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Publication Fee Transferred |
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2025-05-29 10:35 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-01 01:32 |
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Publish the Manuscript Online |
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2025-08-14 05:49 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Observational Study |
| Article Title |
Risk prediction of acute variceal bleeding in hepatocellular carcinoma patients undergoing systemic therapy based on immune checkpoint inhibitors
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xu Zhang, Li-Meng Song, Yu-Piao Zheng, Bao-Xin Qian, Jing Liang and Feng-Mei Wang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Tianjin Key Medical Discipline (Specialty) Construction Project |
TJYXZDXK-034A |
| Hebei Province 2025 Traditional Chinese Medicine Scientific Research Project Plan |
T2025008 |
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| Corresponding Author |
Feng-Mei Wang, PhD, Professor, First Central Hospital of Tianjin Medical University, Tianjin Medical University, Tianjin First Center Hospital, No. 2 Baoshan West Road, Xiyingmen Street, Xiqing District, Tianjin 300380, China. wangfengmeitj@126.com |
| Key Words |
Acute variceal bleeding; Hepatocellular carcinoma; Immune checkpoint inhibitors; Tyrosine kinase inhibitors; Variceal bleeding history; Risk factors |
| Core Tip |
Hepatocellular carcinoma patients with a history of variceal bleeding, tumor diameter ≥ 5 cm, portal vein tumor thrombosis, or elevated fibrosis-4 index (≥ 4.57) are at significantly increase the risk of recurrent variceal bleeding during immune checkpoint inhibitor (ICI)-based systemic therapy. Closely monitor these individuals for early signs of bleeding. Prior to initiating ICIs, consider endoscopic screening in high-risk patients. |
| Publish Date |
2025-08-14 05:49 |
| Citation |
<p>Zhang X, Song LM, Zheng YP, Qian BX, Liang J, Wang FM. Risk prediction of acute variceal bleeding in hepatocellular carcinoma patients undergoing systemic therapy based on immune checkpoint inhibitors. <i>World J Gastrointest Oncol</i> 2025; 17(8): 108887</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i8/108887.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i8.108887 |
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