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Articles Published Processes
9/15/2025 8:37:58 AM | Browse: 174 | Download: 39
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Received |
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2025-04-27 06:40 |
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Peer-Review Started |
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2025-04-27 06:40 |
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To Make the First Decision |
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Return for Revision |
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2025-05-09 03:17 |
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Revised |
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2025-06-04 09:25 |
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Second Decision |
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2025-07-14 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-14 07:04 |
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Articles in Press |
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2025-07-14 07:04 |
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Publication Fee Transferred |
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2025-06-05 13:25 |
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Edit the Manuscript by Language Editor |
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2025-07-28 23:49 |
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Typeset the Manuscript |
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2025-08-28 03:06 |
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Publish the Manuscript Online |
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2025-09-15 08:37 |
| ISSN |
1948-5204 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Research & Experimental Medicine |
| Manuscript Type |
Basic Study |
| Article Title |
Ginsenoside F4 inhibited colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Wei Xie, Xue-Jian Li, Yu-Sen Zhong, Jie Fang, Hui Qi, Meng Yang, Hua-Zhong Ying and Chen-Huan Yu |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Science and Technology Project of the Zhejiang Province |
No. 2020Y |
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| Corresponding Author |
Chen-Huan Yu, Dean, PhD, Senior Researcher, Hangzhou Institute of Medicine, Chinese Academy of Sciences, No. 150 Dongfang Street, Xiasha Sub-district, Qiantang District, Hangzhou 310022, Zhejiang Province, China. yuchenhuan2002@163.com |
| Key Words |
Cytotoxic T lymphocyte; Dendritic cells; Ginsenosides; Sphingosine-1-phosphate 1; Tumor microenvironment |
| Core Tip |
This study provides novel insights into the antitumor effects of natural ginsenoside F4 on the apoptosis of colorectal cancer (CRC) cells by activating the sphingosine-1-phosphate 1-mediated phosphoinositide 3-kinase/protein kinase B and nuclear factor kappa-B pathways in dendritic cells, which subsequently triggers the antitumor effects of cluster of differentiation (CD) 8 + T cells. Further investigation revealed that F4 inhibited tumor growth in CRC-bearing mice by recruiting dendritic cells and CD8 + T cells into the tumor immune microenvironment. These findings underscore the promising role of ginsenoside F4 in the management of CRC, highlighting the potential of natural ginsenosides as an adjuvant treatment for this disease. |
| Publish Date |
2025-09-15 08:37 |
| Citation |
<p>Xie W, Li XJ, Zhong YS, Fang J, Qi H, Yang M, Ying HZ, Yu CH. Ginsenoside F4 inhibited colorectal cancer progression by boosting dendritic cell maturation and remodeling the tumor microenvironment. <i>World J Gastrointest Oncol</i> 2025; 17(9): 108892</p> |
| URL |
https://www.wjgnet.com/1948-5204/full/v17/i9/108892.htm |
| DOI |
https://dx.doi.org/10.4251/wjgo.v17.i9.108892 |
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