| ISSN |
2219-2808 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/ |
| Copyright |
©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Case Control Study |
| Article Title |
Deficiency of anterior pituitary hormones in Noonan syndrome and its impact on response to growth-hormone therapy
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Rajdeep Basu, Soumil Bera, Sunetra Mondal, Sapan Shah, Kumar Swapnil, Roohi Nanda, Joydip Datta, Soumita Mandal, Soumik Goswami, Arjun Baidya and Nilanjan Sengupta |
| ORCID |
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| Funding Agency and Grant Number |
|
| Corresponding Author |
Sunetra Mondal, Assistant Professor, Consultant, DM, FRCP, MD, MRCP, Department of Endocrinology, NRS Medical College and Hospital, 138, AJC Bose Road, Kolkata 700014, West Bengal, India. sunetra59@gmail.com |
| Key Words |
Noonan syndrome; RAS-opathy; Clinico-hormonal profile; Combined pituitary hormone deficiency; Growth hormone therapy |
| Core Tip |
Noonan syndrome (NS), a RASopathy, can be associated with combined pituitary hormone deficiency (CPHD), in addition to isolated growth hormone (GH) deficiency. Hypoplasia of the pituitary gland may be the reason for CPHD in NS. NS with CPHD have shorter height and lower body weight, but can have better response to recombinant GH therapy than NS without CPHD. Children having PTPN11 mutation NS with low insulin-like-growth-factor 1 should be tested for cortisol and thyroid function at baseline to rule out CPHD and if there is a suspicion for CPHD, should undergo periodic testing for cortisol and thyroid function while receiving GH. |
| Publish Date |
2025-10-31 15:02 |
| Citation |
<p>Basu R, Bera S, Mondal S, Shah S, Swapnil K, Nanda R, Datta J, Mandal S, Goswami S, Baidya A, Sengupta N. Deficiency of anterior pituitary hormones in Noonan syndrome and its impact on response to growth-hormone therapy. <i>World J Clin Pediatr</i> 2025; 14(4): 108897</p> |
| URL |
https://www.wjgnet.com/2219-2808/full/v14/i4/108897.htm |
| DOI |
https://dx.doi.org/10.5409/wjcp.v14.i4.108897 |
