BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/24/2025 6:10:09 AM | Browse: 81 | Download: 278
 |
Received |
|
2025-04-27 15:55 |
|
Peer-Review Started |
|
2025-04-27 15:55 |
|
First Decision by Editorial Office Director |
|
2025-05-17 07:38 |
|
Return for Revision |
|
2025-05-17 07:38 |
|
Revised |
|
2025-05-27 13:55 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2025-09-08 02:46 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-09-08 10:46 |
|
Articles in Press |
|
2025-09-08 10:46 |
|
Edit the Manuscript by Language Editor |
|
|
|
Typeset the Manuscript |
|
2025-10-17 01:55 |
|
Publish the Manuscript Online |
|
2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Sidedness matters: Colon cancer outcomes in low-resource settings
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Jaime González-Montero, Guillermo Valenzuela, Carlos I Rojas and Mauricio Burotto |
| ORCID |
|
| Funding Agency and Grant Number |
|
| Corresponding Author |
Jaime González-Montero, Assistant Professor, MD, PhD, Department of Oncology, Bradford Hill Clinical Research Center, Palestina 343, Fifth Floor, Recoleta, Santiago 8420383, Chile. jagonzalez@ug.uchile.cl |
| Key Words |
Colon cancer; Sidedness; Tailored therapy; Mismatch repair; Consensus molecular subtypes |
| Core Tip |
Colon tumor sidedness is a practical compass for determining treatment. This review synthesizes epidemiologic, molecular, and clinical differences between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Older patients with RCC more frequently exhibit microsatellite instability-high status/deficient mismatch repair (MMR), Kirsten rat sarcoma viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 mutations, poorer prognosis in metastatic disease, and limited benefit from anti-epidermal growth factor receptor (EGFR). LCC is more often RAS/v-raf murine sarcoma viral oncogene homolog B1 wild-type and EGFR-responsive. We propose a low-resource plan: Prioritize MMR immunohistochemistry; consider immunotherapy for deficient MMR/microsatellite instability-high; use 5-fluorouracil + leucovorin + oxaliplatin + irinotecan ± anti-angiogenic agents for RCC and doublet ± anti-angiogenic therapy for LCC; restrict anti-EGFR to confirmed wild-type disease. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
González-Montero J, Valenzuela G, Rojas CI, Burotto M. Sidedness matters: Colon cancer outcomes in low-resource settings. World J Clin Oncol 2025; 16(10): 108937 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/108937.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.108937 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
