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Articles Published Processes
10/24/2025 6:10:09 AM | Browse: 39 | Download: 155
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Received |
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2025-04-27 15:55 |
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Peer-Review Started |
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2025-04-27 15:55 |
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First Decision by Editorial Office Director |
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2025-05-17 07:38 |
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Return for Revision |
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2025-05-17 07:38 |
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Revised |
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2025-05-27 13:55 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-09-08 02:46 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-09-08 10:46 |
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Articles in Press |
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2025-09-08 10:46 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-17 01:55 |
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Publish the Manuscript Online |
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2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Sidedness matters: Colon cancer outcomes in low-resource settings
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Jaime González-Montero, Guillermo Valenzuela, Carlos I Rojas and Mauricio Burotto |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Jaime González-Montero, Assistant Professor, MD, PhD, Department of Oncology, Bradford Hill Clinical Research Center, Palestina 343, Fifth Floor, Recoleta, Santiago 8420383, Chile. jagonzalez@ug.uchile.cl |
| Key Words |
Colon cancer; Sidedness; Tailored therapy; Mismatch repair; Consensus molecular subtypes |
| Core Tip |
Colon tumor sidedness is a practical compass for determining treatment. This review synthesizes epidemiologic, molecular, and clinical differences between right-sided colon cancer (RCC) and left-sided colon cancer (LCC). Older patients with RCC more frequently exhibit microsatellite instability-high status/deficient mismatch repair (MMR), Kirsten rat sarcoma viral oncogene homolog/v-raf murine sarcoma viral oncogene homolog B1 mutations, poorer prognosis in metastatic disease, and limited benefit from anti-epidermal growth factor receptor (EGFR). LCC is more often RAS/v-raf murine sarcoma viral oncogene homolog B1 wild-type and EGFR-responsive. We propose a low-resource plan: Prioritize MMR immunohistochemistry; consider immunotherapy for deficient MMR/microsatellite instability-high; use 5-fluorouracil + leucovorin + oxaliplatin + irinotecan ± anti-angiogenic agents for RCC and doublet ± anti-angiogenic therapy for LCC; restrict anti-EGFR to confirmed wild-type disease. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
González-Montero J, Valenzuela G, Rojas CI, Burotto M. Sidedness matters: Colon cancer outcomes in low-resource settings. World J Clin Oncol 2025; 16(10): 108937 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/108937.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.108937 |
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