Publication Name	World Journal of Diabetes
Manuscript ID	108946
Country	China

Received	2025-04-28 10:27
Peer-Review Started	2025-04-29 09:01
To Make the First Decision
Return for Revision	2025-05-20 09:58
Revised	2025-06-02 14:28
Second Decision	2025-07-08 00:23
Accepted by Journal Editor-in-Chief	2025-07-11 09:02
Accepted by Executive Editor-in-Chief	2025-07-14 09:16
Articles in Press	2025-07-14 09:16
Publication Fee Transferred	2025-06-09 07:03
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-01 13:50
Publish the Manuscript Online	2025-08-14 10:52

ISSN	1948-9358 (online)
Open Access	This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
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Category	Pediatrics
Manuscript Type	Case Report
Article Title	WFS1 gene mutation associated with pediatric diabetes mellitus and congenital deafness: A case report
Manuscript Source	Unsolicited Manuscript
All Author List	Ai-Min Gao, Wan-Ling Deng, Xin-Ping Yang, Wan-Yue Wu, Chun-Yuan Ma and Yu Liu
ORCID	Author(s) ORCID Number Yu Liu http://orcid.org/0009-0005-0560-3024
Funding Agency and Grant Number	Funding Agency Grant Number Beijing Holistic Integrative Medicine Association Clinical Research Funding Program ZHKY-2024-2209
Corresponding Author	Yu Liu, Chief Physician, Department of Pediatric Endocrinology, Genetics and Metabolism, Guiyang Maternal and Child Health Care Hospital, Guiyang Children's Hospital, No. 63 Ruijin South Road, Nanming District, Guiyang 550000, Guizhou Province, China. yuliudoctor2@163.com
Key Words	Childhood diabetes mellitus; Congenital deafness; WFS1 gene; Wolfram syndrome; Monogenic diabetes
Core Tip	A 2 year old girl with diabetic ketoacidosis and congenital deafness was found to carry a novel heterozygous WFS1 mutation (c.986T > C, p.Phe329Ser). Rapid whole exome sequencing confirmed Wolfram syndrome, guiding timely metabolic correction, insulin therapy, audiologic support, and genetic counseling. This previously unreported variant expands the WFS1 mutational spectrum and underscores the value of early genetic testing in children whose diabetes presents with atypical features such as sensorineural hearing loss.
Publish Date	2025-08-14 10:52
Citation	<p>Gao AM, Deng WL, Yang XP, Wu WY, Ma CY, Liu Y. WFS1 gene mutation associated with pediatric diabetes mellitus and congenital deafness: A case report. <i>World J Diabetes</i> 2025; 16(8): 108946</p>
URL	https://www.wjgnet.com/1948-9358/full/v16/i8/108946.htm
DOI	https://dx.doi.org/10.4239/wjd.v16.i8.108946

Full Article (PDF)	WJD-16-108946-with-cover.pdf
CARE Checklist–2016	108946-CARE-Checklist-2016.pdf
Manuscript File	108946_Auto_Edited_065015.docx
Answering Reviewers	108946-answering-reviewers.pdf
Audio Core Tip	108946-audio.mp3
Conflict-of-Interest Disclosure Form	108946-conflict-of-interest-statement.pdf
Copyright License Agreement	108946-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	108946-foundation-statement.pdf
Signed Consent for Treatment Form(s) or Document(s)	108946-informed-consent-statement.pdf
Non-Native Speakers of English Editing Certificate	108946-non-native-speakers.pdf
Supplementary Material	108946-supplementary-material.pdf
Peer-review Report	108946-peer-reviews.pdf
Journal Editor-in-Chief Review Report	108946-journal-editor-in-chief.pdf
Scientific Misconduct Check	108946-scientific-misconduct-check.png
Scientific Editor Work List	108946-scientific-editor-work-list.pdf
CrossCheck Report	108946-crosscheck-report.pdf