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Articles Published Processes
10/24/2025 6:10:13 AM | Browse: 16 | Download: 46
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Received |
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2025-04-27 16:22 |
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Peer-Review Started |
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2025-04-27 16:22 |
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To Make the First Decision |
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Return for Revision |
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2025-05-22 11:13 |
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Revised |
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2025-06-02 05:48 |
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Second Decision |
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2025-09-15 02:42 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-17 10:07 |
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Articles in Press |
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2025-09-17 10:07 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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2025-09-18 03:29 |
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Typeset the Manuscript |
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2025-10-16 08:01 |
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Publish the Manuscript Online |
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2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Ze-Kai Li, Jia-Lin Liao, Min-Rui Luo, Shu-Jie Fang, Wei-Zhen Huang and Dong-Yan Zhang |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82272719 |
| Natural Science Foundation of Guangdong Province |
No. 2023A1515012724 and No. 2024A1515013249 |
| Science and Technology Projects in Guangzhou |
No. 2024A04J5205 |
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| Corresponding Author |
Dong-Yan Zhang, Research Fellow, Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong Province, China. 15013091401@163.com |
| Key Words |
Tumor microenvironment; Neurotransmitter signaling; Metabolic reprogramming; Immune evasion; Immunotherapy |
| Core Tip |
This article presents a novel perspective on the role of neural signaling in orchestrating tumor progression through the neuro-metabolic-immune axis within the tumor microenvironment. It illustrates that neurotransmitters can directly regulate immune evasion while also mediating metabolic reprogramming, thereby indirectly facilitating immunosuppression. This integrative framework unveils a dynamic bidirectional network wherein neural signals coordinate both metabolic and immune adaptations, offering new therapeutic targets aimed at disrupting this axis to enhance conventional cancer treatments. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
<p>Li ZK, Liao JL, Luo MR, Fang SJ, Huang WZ, Zhang DY. Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming. <i>World J Clin Oncol</i> 2025; 16(10): 108954</p> |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/108954.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.108954 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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