BPG is committed to discovery and dissemination of knowledge
Articles Published Processes
10/24/2025 6:10:13 AM | Browse: 96 | Download: 248
 |
Received |
|
2025-04-27 16:22 |
|
Peer-Review Started |
|
2025-04-27 16:22 |
|
First Decision by Editorial Office Director |
|
2025-05-22 11:13 |
|
Return for Revision |
|
2025-05-22 11:13 |
|
Revised |
|
2025-06-02 05:48 |
 |
Publication Fee Transferred |
|
|
|
Second Decision by Editor |
|
2025-09-15 02:42 |
|
Second Decision by Editor-in-Chief |
|
|
|
Final Decision by Editorial Office Director |
|
2025-09-17 10:07 |
|
Articles in Press |
|
2025-09-17 10:07 |
|
Edit the Manuscript by Language Editor |
|
2025-09-18 03:29 |
|
Typeset the Manuscript |
|
2025-10-16 08:01 |
|
Publish the Manuscript Online |
|
2025-10-24 06:10 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
|
| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
|
| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Minireviews |
| Article Title |
Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Ze-Kai Li, Jia-Lin Liao, Min-Rui Luo, Shu-Jie Fang, Wei-Zhen Huang and Dong-Yan Zhang |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82272719 |
| Natural Science Foundation of Guangdong Province |
No. 2023A1515012724 and No. 2024A1515013249 |
| Science and Technology Projects in Guangzhou |
No. 2024A04J5205 |
|
| Corresponding Author |
Dong-Yan Zhang, Research Fellow, Department of Radiation Oncology, Nanfang Hospital, Southern Medical University, No. 1838 North Guangzhou Avenue, Guangzhou 510515, Guangdong Province, China. 15013091401@163.com |
| Key Words |
Tumor microenvironment; Neurotransmitter signaling; Metabolic reprogramming; Immune evasion; Immunotherapy |
| Core Tip |
This article presents a novel perspective on the role of neural signaling in orchestrating tumor progression through the neuro-metabolic-immune axis within the tumor microenvironment. It illustrates that neurotransmitters can directly regulate immune evasion while also mediating metabolic reprogramming, thereby indirectly facilitating immunosuppression. This integrative framework unveils a dynamic bidirectional network wherein neural signals coordinate both metabolic and immune adaptations, offering new therapeutic targets aimed at disrupting this axis to enhance conventional cancer treatments. |
| Publish Date |
2025-10-24 06:10 |
| Citation |
Li ZK, Liao JL, Luo MR, Fang SJ, Huang WZ, Zhang DY. Neuro-tumor interactions: Multi-dimensional mechanisms of neurotransmitter regulation in tumor immune evasion and metabolic reprogramming. World J Clin Oncol 2025; 16(10): 108954 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i10/108954.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i10.108954 |
All content on this site: Copyright © 1993-2026 Baishideng Publishing Group Inc, its licensors, and contributors. All rights are reserved, including those for text and data mining, AI training, and similar technologies. For all open access content, the relevant licensing terms apply.
