| ISSN |
1948-9366 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Surgery |
| Manuscript Type |
Case Report |
| Article Title |
Anal adenocarcinoma with perianal Paget's disease: A case report
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Sheng-Wei Wu, Yao Rong, Gui-Jin Chen, Xu-Song Cao, Zheng-Yong Xie, Bei Wu, Hao-Chun Huang, Zhi-Wei Wang and Xiao-Xiang Wu |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Guangdong Provincial Medical Research Fund General Program |
B2025209 |
|
| Corresponding Author |
Xiao-Xiang Wu, Chief Physician, Professor, Department of General Surgery, General Hospital of Southern Theater Command, General Hospital of Southern Theater Command, Guangzhou,, Guangzhou 510000, Guangdong Province, China. 786486617@qq.com |
| Key Words |
Perianal Paget’s disease; Anal canal adenocarcinoma; Extramammary Paget’s disease; Hemorrhoids; Combined abdominoperineal resection; Pathology; Case report |
| Core Tip |
Perianal Paget's disease (PPD), particularly secondary PPD associated with anal adenocarcinoma, is frequently misdiagnosed due to nonspecific symptoms resembling hemorrhoids or eczema. This case highlights a 72-year-old female with a 2-year misdiagnosis history, ultimately confirmed via colonoscopy, biopsy, and immunohistochemistry [IHC; CK7(+)/CK20(+)/CDX2(+)/CEA(+)]. Successful treatment with 3D laparoscopic abdominoperineal resection and extended perianal excision underscores the importance of early IHC testing in refractory perianal symptoms. Key takeaways: (1) Secondary PPD requires high clinical suspicion in elderly patients with chronic perianal lesions; (2) Multimodal diagnostics (endoscopy, biopsy, IHC) are critical to differentiate primary/secondary PPD; (3) Radical resection ensures oncologic safety, while structured follow-up prevents recurrence. |
| Publish Date |
2025-08-25 12:36 |
| Citation |
Wu SW, Rong Y, Chen GJ, Cao XS, Xie ZY, Wu B, Huang HC, Wang ZW, Wu XX. Anal adenocarcinoma with perianal Paget's disease: A case report. World J Gastrointest Surg 2025; 17(8): 108963 |
| URL |
https://www.wjgnet.com/1948-9366/full/v17/i8/108963.htm |
| DOI |
https://dx.doi.org/10.4240/wjgs.v17.i8.108963 |
