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Articles Published Processes
11/4/2025 2:41:48 AM | Browse: 2 | Download: 0
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Received |
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2025-04-27 15:25 |
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Peer-Review Started |
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2025-04-28 07:09 |
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To Make the First Decision |
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Return for Revision |
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2025-05-12 02:27 |
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Revised |
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2025-05-25 19:01 |
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Second Decision |
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2025-09-01 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-09-01 11:11 |
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Articles in Press |
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2025-09-01 11:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-10-21 09:50 |
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Publish the Manuscript Online |
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2025-11-04 02:41 |
| ISSN |
2220-3206 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Neurosciences |
| Manuscript Type |
Observational Study |
| Article Title |
Polymorphic variants in GABA-A receptor and their association with epilepsy and drug resistance: A North Indian cohort study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Pradeep Kumar Dabla, Swati Singh, Aroop Viswas, Swapan Gupta, Manisha Yadav, Subash C Sonkar, Bidhan C Koner and Nafija Serdarevic |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Pradeep Kumar Dabla, MD, Professor, Department of Biochemistry, Govind Ballabh Pant Institute of Postgraduate Medical Education and Research, 1 Jawaharlal Nehru Marg, 64 Khamba, Raj Ghat, New Delhi 110002, Delhi, India. pradeep.dabla@gmail.com |
| Key Words |
Epilepsy; Single nucleotide polymorphism; Drug-resistant epilepsy; Gamma-aminobutyric acid type A receptor; GABRA1 rs2279020; GABRG2 rs211013 |
| Core Tip |
The limited available data have shown association of gamma-aminobutyric acid (GABA) receptors as a key target in the pathophysiology of epilepsy. Prior studies have hypothesized that polymorphism in genes that encode the α1 and γ2 subunits of the GABA-A receptor protein, alters the channel’s structure-function, potentially leading to medication resistance. However, limited data is available on the relationship between GABA receptor variants and drug resistance in human subjects. In our present study, we aim to elucidate the role of GABA-A subunit variants in the development of anti-epileptic drug resistance, which could inform more personalized treatment strategies for individuals with epilepsy, ultimately improving their health outcomes. |
| Publish Date |
2025-11-04 02:41 |
| Citation |
<p>Dabla PK, Singh S, Viswas A, Gupta S, Yadav M, Sonkar SC, Koner BC, Serdarevic N. Polymorphic variants in GABA-A receptor and their association with epilepsy and drug resistance: A North Indian cohort study. <i>World J Psychiatry</i> 2025; 15(11): 108964</p> |
| URL |
https://www.wjgnet.com/2220-3206/full/v15/i11/108964.htm |
| DOI |
https://dx.doi.org/10.5498/wjp.v15.i11.108964 |
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