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Articles Published Processes
8/18/2025 10:04:51 AM | Browse: 2 | Download: 0
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Received |
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2025-04-27 05:49 |
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Peer-Review Started |
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2025-04-27 05:49 |
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To Make the First Decision |
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Return for Revision |
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2025-06-18 07:28 |
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Revised |
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2025-07-01 19:12 |
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Second Decision |
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2025-07-24 02:38 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-24 03:09 |
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Articles in Press |
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2025-07-24 03:09 |
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Publication Fee Transferred |
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2025-07-02 14:06 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-08 01:46 |
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Publish the Manuscript Online |
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2025-08-18 10:04 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Medical Laboratory Technology |
| Manuscript Type |
Observational Study |
| Article Title |
Age- and gender-specific dynamics and next-generation reference intervals for pepsinogen in northern China
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Miao-Miao Zhang, Dong Zhu, Hai-Bin Zhao and Xiu-Ying Zhao |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Dong Zhu, Associate Chief Physician, Department of Laboratory Medicine, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua Medicine, Tsinghua University, No. 168 Litang Road, Changping District, Beijing 102218, China. zhudongcherish@163.com |
| Key Words |
Pepsinogen; Reference intervals; Next-generation reference intervals; Age dynamics; Gastric biomarkers; Personalized medicine |
| Core Tip |
This study pioneers the establishment of next-generation reference intervals (RIs) for pepsinogen (PG) in Chinese adults and elderly populations using Generalized Additive Models for Location, Scale, and Shape. We identified age- and sex-specific dynamics: PG I and PG II levels increased with age (PG I plateaued post-60 years; PG II rose continuously), with males exhibiting higher values. Partitioned RIs based on age were established, but next-generation RIs demonstrated superior accuracy. By capturing continuous physiological trends, next-generation RIs could potentially reduce diagnostic misinterpretation. |
| Publish Date |
2025-08-18 10:04 |
| Citation |
<p>Zhang MM, Zhu D, Zhao HB, Zhao XY. Age- and gender-specific dynamics and next-generation reference intervals for pepsinogen in northern China. <i>World J Gastroenterol</i> 2025; 31(31): 108977</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i31/108977.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i31.108977 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
California Corporate Number: 3537345
