| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Permissions |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Pathology |
| Manuscript Type |
Basic Study |
| Article Title |
Clinicopathological significance of histological diversity in gastric adenocarcinoma with primitive enterocyte phenotype: A methylation-driven aggressive entity
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Hou-Qiang Li, Lan-Qing Zheng, Wen-Tao Huang, Xun-Bin Yu, Xia Zhang, Lan Lin, Shan-Shan Lv, Xi-Yao Yan and Xiao-Yan Chen |
| ORCID |
|
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Startup Fund for Scientific Research, Fujian Medical University, |
No. 2020QH1168 |
| Fujian Provincial Science and Technology Innovation Joint Funds |
No. 2024Y9023 |
| Fujian Provincial Natural Science Foundation of China |
No. 2024J011644 |
|
| Corresponding Author |
Hou-Qiang Li, Researcher, Department of Pathology, Fuzhou University Affiliated Provincial Hospital, No. 134 East Street, Fuzhou 350001, Fujian Province, China. docli254@163.com |
| Key Words |
Gastric cancer; Gastric adenocarcinoma with enteroblastic differentiation; Hepatoid adenocarcinoma; Alpha-fetoprotein; Bioinformatics; Methylation |
| Core Tip |
Gastric adenocarcinoma with primitive enterocyte phenotype (GAPEP) exhibits aggressive behavior and diverse morphologies, including tubular-papillary and solid types, which necessitate integrated histopathological, immunohistochemical, and molecular experiments for accurate identification. This study highlighted GAPEP’s methylation-driven pathogenesis, with methylation dysregulation (e.g., DNMT3A/B/L, TET1/3 and EZH2 upregulation). Gastric adenocarcinoma with enteroblastic differentiation and hepatoid adenocarcinoma shared similar clinicopathological and genetic features, suggesting a common origin. Targeting methylation pathways (e.g., DNMT inhibitors) offers potential therapeutic avenues for this lethal cancer, emphasizing the critical role of epigenetic mechanisms in the pathogenesis of GAPEP. |
| Publish Date |
2025-07-24 07:47 |
| Citation |
<p>Li HQ, Zheng LQ, Huang WT, Yu XB, Zhang X, Lin L, Lv SS, Yan XY, Chen XY. Clinicopathological significance of histological diversity in gastric adenocarcinoma with primitive enterocyte phenotype: A methylation-driven aggressive entity. <i>World J Gastroenterol</i> 2025; 31(28): 108990</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i28/108990.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i28.108990 |
