Publication Name	World Journal of Stem Cells
Manuscript ID	109006
Country	China

Received	2025-04-28 11:36
Peer-Review Started	2025-04-28 11:37
To Make the First Decision
Return for Revision	2025-05-24 02:42
Revised	2025-06-06 18:42
Second Decision	2025-07-14 02:43
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-28 08:29
Articles in Press	2025-07-28 08:29
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-11 07:11
Publish the Manuscript Online	2025-08-21 05:29

ISSN	1948-0210 (online)
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Category	Geriatrics & Gerontology
Manuscript Type	Review
Article Title	Mesenchymal stem cell-derived exosomes: Shaping the next era of Alzheimer’s disease treatment
Manuscript Source	Invited Manuscript
All Author List	Xiao-Qian Shan, Mei-Heng He, Wei-Li Gao, Yu-Jiao Li, Shu-Zhen Liu, Yan Liu, Chao-Li Wang, Lan Zhao and Shi-Xin Xu
ORCID	Author(s) ORCID Number Xiao-Qian Shan http://orcid.org/0000-0002-9473-0949 Mei-Heng He http://orcid.org/0009-0002-9068-5594 Wei-Li Gao http://orcid.org/0009-0003-6290-1832 Yu-Jiao Li http://orcid.org/0000-0003-4949-2942 Shu-Zhen Liu http://orcid.org/0009-0009-4735-3456 Yan Liu http://orcid.org/0009-0002-9736-8145 Chao-Li Wang http://orcid.org/0009-0005-0097-9356 Lan Zhao http://orcid.org/0000-0002-7449-2947 Shi-Xin Xu http://orcid.org/0000-0003-2270-2911
Funding Agency and Grant Number	Funding Agency Grant Number National Natural Science Foundation of China 82074533
Corresponding Author	Lan Zhao, First Teaching Hospital of Tianjin University of Traditional Chinese Medicine, National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion, No. 88 Changling Road, Xiqing District, Tianjin 300381, China. lanzhao69@163.com
Key Words	Alzheimer’s disease; Mesenchymal stem cells; Exosomes; Precision medicine; Cell-free therapy
Core Tip	Mesenchymal stem cell-derived exosomes represent a promising therapeutic modality for Alzheimer’s disease, owing to their biological functions and biocompatibility. Mesenchymal stem cell-derived exosomes facilitate the clearance of β-amyloid by carrying degradative enzymes, modulate neuroinflammation, and promote neurorestoration. While preclinical and clinical data are encouraging, challenges such as production standardization, safety, and long-term efficacy remain. Strategies like exosome functionalization, targeting optimization, gene editing, and synthetic exosomes may enhance therapeutic potential and accelerate clinical translation.
Publish Date	2025-08-21 05:29
Citation	<p>Shan XQ, He MH, Gao WL, Li YJ, Liu SZ, Liu Y, Wang CL, Zhao L, Xu SX. Mesenchymal stem cell-derived exosomes: Shaping the next era of Alzheimer’s disease treatment. <i>World J Stem Cells</i> 2025; 17(8): 109006</p>
URL	https://www.wjgnet.com/1948-0210/full/v17/i8/109006.htm
DOI	https://dx.doi.org/10.4252/wjsc.v17.i8.109006

Full Article (PDF)	WJSC-17-109006-with-cover.pdf
Manuscript File	109006_Auto_Edited_065655.docx
Answering Reviewers	109006-answering-reviewers.pdf
Audio Core Tip	109006-audio.m4a
Conflict-of-Interest Disclosure Form	109006-conflict-of-interest-statement.pdf
Copyright License Agreement	109006-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	109006-foundation-statement.pdf
Non-Native Speakers of English Editing Certificate	109006-non-native-speakers.pdf
Supplementary Material	109006-supplementary-material.pdf
Peer-review Report	109006-peer-reviews.pdf
Scientific Misconduct Check	109006-scientific-misconduct-check.png
Scientific Editor Work List	109006-scientific-editor-work-list.pdf
CrossCheck Report	109006-crosscheck-report.pdf