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Articles Published Processes
10/11/2025 9:30:02 AM | Browse: 15 | Download: 52
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Received |
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2025-04-28 08:48 |
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Peer-Review Started |
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2025-04-28 08:48 |
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To Make the First Decision |
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Return for Revision |
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2025-05-15 10:05 |
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Revised |
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2025-05-19 17:45 |
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Second Decision |
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2025-08-11 02:52 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-11 12:11 |
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Articles in Press |
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2025-08-11 12:11 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-15 07:01 |
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Publish the Manuscript Online |
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2025-10-11 09:30 |
| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Review |
| Article Title |
Advancing the management of primary biliary cholangitis: From pathogenesis to emerging therapies
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Armando Curto, Rocco G Iamello, Erica N Lynch and Andrea Galli |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Erica N Lynch, MD, Gastroenterology Research Unit, Department of Experimental and Clinical Biomedical Sciences “Mario Serio”, University of Florence, Largo Brambilla 3, Florence 50134, Tuscany, Italy. ericanicola.lynch@unifi.it |
| Key Words |
Pruritus; Fatigue; Obeticholic acid; Cholestasis; Gut-liver axis; Peroxisome proliferator-activated receptors; Ursodeoxycholic acid; Primary biliary cholangitis |
| Core Tip |
Primary biliary cholangitis (PBC) is a progressive autoimmune liver disease driven by a complex interplay of genetic, environmental, and microbial factors. Despite advances in early diagnosis and the widespread use of ursodeoxycholic acid, a significant subset of patients experiences incomplete biochemical response and disease progression. This review highlights recent breakthroughs in understanding PBC pathogenesis, the limitations of current therapies, including the withdrawal of obeticholic acid, and the emerging role of novel agents such as selective peroxisome proliferator-activated receptors agonists. Future strategies focusing on early intervention, personalized treatment, and symptom management may reshape the clinical management and prognosis of PBC. |
| Publish Date |
2025-10-11 09:30 |
| Citation |
<p>Curto A, Iamello RG, Lynch EN, Galli A. Advancing the management of primary biliary cholangitis: From pathogenesis to emerging therapies. <i>World J Clin Cases</i> 2025; 13(30): 109028</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i30/109028.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i30.109028 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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