| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Clinical Trials Study |
| Article Title |
Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Veronica Bernabucci, Alessia Ciancio, Salvatore Petta, Aimilia Karampatou, Laura Turco, Silvia Strona, Rosina Critelli, Paola Todesca, Caterina Cerami, Caterina Sagnelli, Mario Rizzetto, Calogero Cammà and Erica Villa |
| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| Schering-Plough (now Merck) |
|
|
| Corresponding Author |
Erica Villa, Professor, Division of Gastroenterology, Azienda Ospedaliero-Universitaria Policlinico di Modena, Università degli Studi di Modena e Reggio Emilia, via del Pozzo 71, 41124 Modena, Italy. erica.villa@unimore.it |
| Key Words |
Hepatitis C virus treatment; Pegylated Interferon; Viral Hepatitis; Menopause; Genotype 1 |
| Core Tip |
After menopause liver disease in hepatitis C virus-positive women becomes rapidly progressive, severe fibrosis develops, and response to antiviral therapy becomes very low. Re-treatment with standard dual therapy in previous failures of Peginterferon-??+ Ribavirin (PEG-IFN?/RBV) treatments does not achieve more than 5%-10% sustained virological response (SVR). The addition of Boceprevir to PEG-IFN?/RBV in menopausal women with HCV-1 genotype infection, who had previously failed dual antiviral therapy, determined a striking improvement of SVR. More than 45% of women re-treated with triple therapy achieved SVR, with few side effects and good tolerability. Response after 4 wk of Boceprevir was the only independent factor predicting SVR. |
| Publish Date |
2014-12-02 10:46 |
| Citation |
Bernabucci V, Ciancio A, Petta S, Karampatou A, Turco L, Strona S, Critelli R, Todesca P, Cerami C, Sagnelli C, Rizzetto M, Cammà C, Villa E. Boceprevir is highly effective in treatment-experienced hepatitis C virus-positive genotype-1 menopausal women. World J Gastroenterol 2014; 20(44): 16726-16733 |
| URL |
http://www.wjgnet.com/1007-9327/full/v20/i44/16726.htm |
| DOI |
http://dx.doi.org/10.3748/wjg.v20.i44.16726 |
