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Articles Published Processes
7/24/2025 9:11:34 AM | Browse: 2 | Download: 0
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Received |
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2025-04-29 06:53 |
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Peer-Review Started |
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2025-04-29 06:53 |
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To Make the First Decision |
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Return for Revision |
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2025-05-17 08:34 |
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Revised |
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2025-05-17 13:56 |
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Second Decision |
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2025-07-01 02:35 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-07-01 09:16 |
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Articles in Press |
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2025-07-01 09:16 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-15 14:51 |
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Publish the Manuscript Online |
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2025-07-24 09:11 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Respiratory System |
| Manuscript Type |
Letter to the Editor |
| Article Title |
Long noncoding ribonucleic acid ENST00000517482 enhances mesenchymal stem cell therapy against acute lung injury
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Yan Zhou, Bo-Tao Xu, Hai-Ying Zhou and Zhong-Tu Shang |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yan Zhou, MD, Department of Respiratory Medicine, Zhuji People’s Hospital, No. 9 Jianmin Road, Taozhu Street, Zhuji 311800, Zhejiang Province, China. 13606850272@163.com |
| Key Words |
Acute lung injury; AMP-activated protein kinase/c-jun-N-terminal kinase; Autophagy; ENST00000517482; Extracellular vesicles; Mesenchymal stem cell; MicroRNA-539/c-MYC axis; Phosphatidylinositol 3-kinase/protein kinase B/mammalian target of the rapamycin; Stem-cell therapy |
| Core Tip |
Long non-coding RNA ENST00000517482 enhances the survival of mesenchymal stem cells by protecting mitochondria from apoptosis through the microRNA-539 and c-MYC signaling axis. While this mechanism strengthens stem cell paracrine effects in vitro, its simultaneous activation of autophagy poses potential risks of aggravating lung tissue injury in living organisms. Furthermore, conventional systemic infusion of mesenchymal stem cells results in limited therapeutic efficiency due to poor lung targeting. This article emphasizes the importance of controlling autophagy levels and adopting extracellular vesicle-based delivery systems as critical steps to translate ENST00000517482-mediated stem cell therapies into safe and effective treatments for acute lung injury. |
| Publish Date |
2025-07-24 09:11 |
| Citation |
<p>Zhou Y, Xu BT, Zhou HY, Shang ZT. Long noncoding ribonucleic acid ENST00000517482 enhances mesenchymal stem cell therapy against acute lung injury. <i>World J Stem Cells</i> 2025; 17(7): 109064</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i7/109064.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i7.109064 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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