| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Minireviews |
| Article Title |
Appendiceal mucinous neoplasms: Optimizing treatment strategies based on clinical, histological, and molecular features
|
| Manuscript Source |
Invited Manuscript |
| All Author List |
Atsushi Mitamura, Shingo Tsujinaka, Fumiyoshi Fujishima, Kentaro Sawada, Makoto Hikage, Tomoya Miura, Yoh Kitamura, Yuuri Hatsuzawa, Toru Nakano and Chikashi Shibata |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Shingo Tsujinaka, Associate Professor, MD, Division of Gastroenterologic Surgery, Department of Surgery, Tohoku Medical and Pharmaceutical University, 1-15-1 Fukumuro, Miyagino-ku, Sendai 983-8356, Miyagi, Japan. tsujinakas@tohoku-mpu.ac.jp |
| Key Words |
Low-grade appendiceal neoplasms; High-grade appendiceal neoplasms; Mucinous adenocarcinomas; Pseudomyxoma peritonei; Immunohistochemistry; Molecular markers; Cytoreductive surgery; Hyperthermic intraperitoneal chemotherapy |
| Core Tip |
Appendiceal mucinous neoplasms (AMNs) are rare tumors originating in mucin-producing epithelial cells of the appendix. They can be benign or malignant. AMN is often discovered during appendectomy, presenting asymptomatically or mimicking acute appendicitis. Noninvasive AMNs include low-grade and high-grade lesions, whereas invasive types are mucinous adenocarcinomas. Rupture may lead to pseudomyxoma peritonei (PMP). Surgery is the primary treatment, with options including appendectomy, hemicolectomy, or cytoreductive surgery with chemotherapy. Histological diagnosis involves mucin detection and immunohistochemistry markers. Molecular profiling has revealed mutations in KRAS (favorable prognosis) and GNAS and TP53 (poor prognosis), guiding treatment strategies for AMN and PMP. |
| Publish Date |
2025-08-20 08:41 |
| Citation |
Mitamura A, Tsujinaka S, Fujishima F, Sawada K, Hikage M, Miura T, Kitamura Y, Hatsuzawa Y, Nakano T, Shibata C. Appendiceal mucinous neoplasms: Optimizing treatment strategies based on clinical, histological, and molecular features. World J Clin Oncol 2025; 16(8): 109088 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i8/109088.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i8.109088 |
