Publication Name	World Journal of Cardiology
Manuscript ID	10909
Country	United States

Received	2014-04-25 08:48
Peer-Review Started	2014-04-28 22:50
To Make the First Decision	2014-05-14 13:36
Return for Revision	2014-05-20 20:56
Revised	2014-08-15 00:00
Second Decision	2014-09-10 13:37
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-09-10 13:59
Articles in Press	2014-09-10 13:59
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 15:36
Publish the Manuscript Online	2014-12-01 14:43

ISSN	1949-8462 (online)
Open Access
Copyright
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Website	http://www.wjgnet.com

Category	Cardiac & Cardiovascular Systems
Manuscript Type	Topic Highlights
Article Title	Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and non-ischemic myocardial pathologies
Manuscript Source	Invited Manuscript
All Author List	Maythem Saeed, Steven W Hetts, Robert Jablonowski and Mark W Wilson
Funding Agency and Grant Number
Corresponding Author	Maythem Saeed, Professor, Department of Radiology and Biomedical Imaging, School of Medicine, University of California San Francisco, 185 Berry Street, Suite 350, Campus Box 0946, San Francisco, CA 94107-5705, United States. maythem.saeed@ucsf.edu
Key Words	Myocardial viability; Ischemic/non-ischemic heart diseases; Magnetic resonance imaging; Multi-detector computed tomography; Cellular compartments; Contrast media
Core Tip	This review addresses recent advances of measuring of extracellular volume (ECV) in ischemic and non-ischemic myocardial pathologies. The main approaches that are used for probing ECV are equilibrium contrast enhanced magnetic resonance imaging/multi-detector computed tomography and magnetic resonance imaging (MRI) longitudinal relaxation time mapping. These noninvasive techniques are currently used, but at a lower scale, as alternative to invasive endomyocardial biopsies to eliminate anesthesia, coronary catheterization and tissue sampling error. ECV measurements may aid in early detection of various myocardial pathologies. Delayed contrast enhanced-MRI (DE-MRI) and when T1-mapping demonstrated sub-epicardium, sub-endocardial and patchy mid-myocardial enhancement in myocarditis, Behcet’s disease and sarcoidosis, respectively. Furthermore, recent studies showed that the combined technique of cine, T2-weighted and DE-MRI technique has high diagnostic accuracy for detecting myocarditis. When the tomographic techniques are coupled with myocardial perfusion and left ventricular function it can provide valuable information on the progression of myocardial pathologies and effectiveness of new therapies.
Publish Date	2014-12-01 14:43
Citation	Saeed M, Hetts SW, Jablonowski R, Wilson MW. Magnetic resonance imaging and multi-detector computed tomography assessment of extracellular compartment in ischemic and non-ischemic myocardial pathologies. World J Cardiol 2014; 6(11): 1192-1208
URL	http://www.wjgnet.com/1949-8462/full/v6/i11/1192.htm
DOI	http://dx.doi.org/10.4330/wjc.v6.i11.1192

Full Article (PDF)	WJC-6-1192.pdf
Full Article (Word)	WJC-6-1192.doc
Manuscript File	10909-Review.docx
Answering Reviewers	10909-Answering reviewers.pdf
Copyright License Agreement	10909-Copyright assignment.pdf
Peer-review Report	10909-Peer review(s).pdf
Scientific Misconduct Check	10909-CrossCheck.jpg
Scientific Editor Work List	10909-Scientific editor work list.pdf