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Articles Published Processes
9/24/2025 3:48:37 AM | Browse: 8 | Download: 39
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Received |
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2025-04-30 07:31 |
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Peer-Review Started |
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2025-04-30 07:31 |
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To Make the First Decision |
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Return for Revision |
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2025-05-24 02:42 |
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Revised |
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2025-06-16 21:04 |
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Second Decision |
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2025-08-10 13:58 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-08-18 08:48 |
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Articles in Press |
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2025-08-18 08:48 |
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Publication Fee Transferred |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-03 08:21 |
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Publish the Manuscript Online |
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2025-09-24 03:48 |
| ISSN |
1948-0210 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Biochemistry & Molecular Biology |
| Manuscript Type |
Review |
| Article Title |
HOX and MEINOX in cellular plasticity, fibrosis, and cancer
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Mustafa Keleş and Aysen Gunel-Ozcan |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Aysen Gunel-Ozcan, Department of Stem Cell Sciences, Graduate School of Health Sciences, Hacettepe University, Altindag, Ankara 06100, Türkiye. aysen.ozcan@hacettepe.edu.tr |
| Key Words |
HOX; MEIS; MEINOX; PKNOX; Fibrosis; Cancer; Molecular signaling pathways |
| Core Tip |
HOX transcription factors and MEINOX cofactors critically regulate positional identity and cellular plasticity, fundamental processes in development and adult tissue homeostasis. Dysregulation of these factors profoundly influences extracellular matrix remodeling and epithelial-mesenchymal transition, promoting fibrosis progression and cancer invasiveness. By highlighting specific HOX-MEINOX-mediated mechanisms underlying disease pathology, including their interactions with key signaling pathways (transforming growth factor-beta, Wnt, Notch), this review identifies novel therapeutic targets. Modulating HOX-MEINOX activity could offer innovative strategies to reverse aberrant epithelial-mesenchymal transition and extracellular matrix remodeling, bridging translational gaps toward effective treatments for fibrotic diseases and cancer. |
| Publish Date |
2025-09-24 03:48 |
| Citation |
<p>Keleş M, Gunel-Ozcan A. HOX and MEINOX in cellular plasticity, fibrosis, and cancer. <i>World J Stem Cells</i> 2025; 17(9): 109102</p> |
| URL |
https://www.wjgnet.com/1948-0210/full/v17/i9/109102.htm |
| DOI |
https://dx.doi.org/10.4252/wjsc.v17.i9.109102 |
© 2004-2025 Baishideng Publishing Group Inc. All rights reserved. 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
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