Publication Name	World Journal of Hepatology
Manuscript ID	10912
Country	Egypt

Received	2014-04-25 08:34
Peer-Review Started	2014-04-28 22:40
To Make the First Decision	2014-05-23 15:11
Return for Revision	2014-08-06 14:16
Revised	2014-08-20 00:00
Second Decision	2014-10-27 16:41
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2014-10-27 17:01
Articles in Press	2014-10-27 17:01
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript	2014-11-20 09:16
Publish the Manuscript Online	2014-11-20 19:46

ISSN	1948-5182 (online)
Open Access
Copyright
Article Reprints	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions	For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher	Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website	http://www.wjgnet.com

Category	Gastroenterology & Hepatology
Manuscript Type	Case Report
Article Title	Circulating microRNA, miR-122 and miR-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma
Manuscript Source	Unsolicited Manuscript
All Author List	Hassan El-Garem, Ayman Ammer, Hany Shehab, Olfat Shaker, Mohammed Anwer, Wafaa El-Akel and Heba Omar
Funding Agency and Grant Number
Corresponding Author	Heba Omar, Msc, PhD, Endemic Medicine and Hepatology Department, Faculty of medicine, 16 Azam Street, Helwan, Cairo 12613, Egypt. hebaomar1202@hotmail.com
Key Words	MiRNA; Hepatocellular carcinoma; Serum
Core Tip	In the current study a signature of circulating miRNAs (miR-122 and miR-221) was evaluated. miR-221 was differentially expressed between patients with hepatocellular carcinoma and those without (chronic hepatitis and liver cirrhosis) with lower serum level of miR-221 in former group of patients in comparison to later one. miR-221 yielded 87% sensitivity and 40% specificity in differentiating between both groups at a cutoff 1.82 folds. The present study emphasizes that circulating miR-221 deserves further attention as a potential non-invasive biomarkers for hepatocellular carcinoma.
Publish Date	2014-11-20 19:46
Citation	El-Garem H, Ammer A, Shehab H, Shaker O, Anwer M, El-Akel W, Omar H. Circulating microRNA, miR-122 and miR-221 signature in Egyptian patients with chronic hepatitis C related hepatocellular carcinoma. World J Hepatol 2014; 6(11): 818-824
URL	http://www.wjgnet.com/1948-5182/full/v6/i11/818.htm
DOI	http://dx.doi.org/10.4254/wjh.v6.i11.818

Full Article (PDF)	WJH-6-818.pdf
Full Article (Word)	WJH-6-818.doc
Manuscript File	10912-Review.doc
Answering Reviewers	10912-Answering reviewers.pdf
Copyright License Agreement	10912-Copyright assignment.pdf
Institutional Review Board Approval Form or Document	Ethics_Committee_20140425061015.docx
Non-Native Speakers of English Editing Certificate	10912-Language certificate.pdf
Peer-review Report	10912-Peer review(s).pdf
Scientific Misconduct Check	10912-CrossCheck.jpg
Scientific Editor Work List	10912-Scientific editor work list.pdf