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Articles Published Processes
9/11/2025 9:41:59 AM | Browse: 293 | Download: 385
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Received |
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2025-05-07 07:06 |
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Peer-Review Started |
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2025-05-08 07:01 |
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First Decision by Editorial Office Director |
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2025-06-05 04:18 |
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Return for Revision |
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2025-06-05 04:18 |
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Revised |
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2025-06-18 11:21 |
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Publication Fee Transferred |
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2025-06-21 09:58 |
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Second Decision by Editor |
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2025-08-14 03:09 |
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Second Decision by Editor-in-Chief |
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2025-08-16 08:33 |
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Final Decision by Editorial Office Director |
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2025-08-20 09:34 |
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Articles in Press |
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2025-08-20 09:34 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-09-03 01:00 |
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Publish the Manuscript Online |
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2025-09-11 09:41 |
| ISSN |
1948-9358 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Endocrinology & Metabolism |
| Manuscript Type |
Retrospective Study |
| Article Title |
Exogenous insulin-associated autoimmunity and the emergence of double diabetes in type 2 diabetes
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Xin-Gang Li, Meng-Ya Qi, Xiang Li and Fan Ping |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| CAMS Innovation Fund for Medical Sciences |
2021-I2M-1-002 |
| Healthcare Quality and Safety Incubation Programme of the Peking Union Medical Foundation |
XHFY 2406 |
| the National High-Level Hospital Clinical Research Funding |
2022-PUMCH-B-015 |
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| Corresponding Author |
Fan Ping, Professor, Department of Endocrinology, Key Laboratory of Endocrinology of National Health Commission, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences & Peking Union Medical College, No. 1 Shuai Fu Yuan, Dongcheng District, Beijing 100730, China. pingfan6779@163.com |
| Key Words |
Double diabetes; Insulin autoantibodies; Exogenous insulin; β-cell failure; Human leukocyte antigen genotype |
| Core Tip |
We report a rare and under-recognized subtype of double diabetes, in which insulin autoantibodies induced by exogenous insulin therapy accelerate β-cell failure in patients with type 2 diabetes. This immune-mediated phenotype-predominantly observed in East Asian populations and associated with high-risk human leukocyte antigen class II alleles highlights a novel immunogenetic mechanism underlying diabetes progression. |
| Publish Date |
2025-09-11 09:41 |
| Citation |
Li XG, Qi MY, Li X, Ping F. Exogenous insulin-associated autoimmunity and the emergence of double diabetes in type 2 diabetes. World J Diabetes 2025; 16(9): 109130 |
| URL |
https://www.wjgnet.com/1948-9358/full/v16/i9/109130.htm |
| DOI |
https://dx.doi.org/10.4239/wjd.v16.i9.109130 |
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