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8/8/2025 9:09:11 AM | Browse: 21 | Download: 77
Publication Name World Journal of Orthopedics
Manuscript ID 109149
Country China
Received
2025-05-06 09:46
Peer-Review Started
2025-05-06 09:46
To Make the First Decision
Return for Revision
2025-06-10 07:14
Revised
2025-06-13 02:26
Second Decision
2025-07-10 02:44
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief
2025-07-10 07:46
Articles in Press
2025-07-10 07:46
Publication Fee Transferred
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-08-01 03:45
Publish the Manuscript Online
2025-08-08 09:09
ISSN 2218-5836 (online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright © The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Orthopedics
Manuscript Type Editorial
Article Title Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives
Manuscript Source Invited Manuscript
All Author List Ren-Xian Xie, Yi-Xuan Xing and Nian-Zhe Sun
ORCID
Author(s) ORCID Number
Ren-Xian Xie http://orcid.org/0009-0007-3150-4382
Yi-Xuan Xing http://orcid.org/0009-0004-7804-3016
Nian-Zhe Sun http://orcid.org/0000-0001-7660-110X
Funding Agency and Grant Number
Corresponding Author Nian-Zhe Sun, MD, Department of Orthopedics, Xiangya Hospital, Central South University, No. 87 Xiangya Road, Kaifu District, Changsha 410008, Hunan Province, China. sunnzh201921@sina.com
Key Words Biomaterials; Bone regeneration; Fibrin sealant; Hydroxyapatite; Regenerative medicine
Core Tip The integration of synthetic biomaterials, for example hydroxyapatite and β-tricalcium phosphate, with fibrin derivatives enhances bone regeneration by improving scaffold stability, cellular recruitment, and mechanical support. While promising, clinical adoption requires standardized protocols, long-term outcome validation, and personalized approaches to address complex bone defects in aging and comorbid populations.
Publish Date 2025-08-08 09:09
Citation <p>Xie RX, Xing YX, Sun NZ. Advancing bone regeneration: Clinical implications of synthetic biomaterials and fibrin derivatives. <i>World J Orthop</i> 2025; 16(8): 109149</p>
URL https://www.wjgnet.com/2218-5836/full/v16/i8/109149.htm
DOI https://dx.doi.org/10.5312/wjo.v16.i8.109149
Full Article (PDF) WJO-16-109149-with-cover.pdf
Manuscript File 109149_Auto_Edited_014029.docx
Answering Reviewers 109149-answering-reviewers.pdf
Audio Core Tip 109149-audio.m4a
Conflict-of-Interest Disclosure Form 109149-conflict-of-interest-statement.pdf
Copyright License Agreement 109149-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 109149-non-native-speakers.pdf
Peer-review Report 109149-peer-reviews.pdf
Scientific Misconduct Check 109149-scientific-misconduct-check.png
Scientific Editor Work List 109149-scientific-editor-work-list.pdf
CrossCheck Report 109149-crosscheck-report.pdf