Publication Name	World Journal of Gastrointestinal Surgery
Manuscript ID	109155
Country	China

Received	2025-04-30 08:39
Peer-Review Started	2025-04-30 08:39
To Make the First Decision
Return for Revision	2025-05-17 03:40
Revised	2025-05-28 05:32
Second Decision	2025-07-07 02:39
Accepted by Journal Editor-in-Chief
Accepted by Executive Editor-in-Chief	2025-07-07 06:32
Articles in Press	2025-07-07 06:32
Publication Fee Transferred	2025-06-05 05:46
Edit the Manuscript by Language Editor
Typeset the Manuscript	2025-08-07 09:27
Publish the Manuscript Online	2025-08-25 12:36

ISSN	1948-9366 (online)
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Category	Gastroenterology & Hepatology
Manuscript Type	Prospective Study
Article Title	Correlation between laparoscopic radical resection and tumor markers in peritoneal irrigation fluid
Manuscript Source	Unsolicited Manuscript
All Author List	Jin-Feng Zhou, Wei Qiu, Jian-Sheng Chen, Bao-Quan Yan, Xiao-Hui Feng, Mei-Zhen Xu and Ji-Ping Yang
ORCID	Author(s) ORCID Number Jin-Feng Zhou http://orcid.org/0009-0008-4238-2904 Wei Qiu http://orcid.org/0000-0002-9517-354X Jian-Sheng Chen http://orcid.org/0009-0002-7909-0987 Bao-Quan Yan http://orcid.org/0009-0006-6119-8016 Xiao-Hui Feng http://orcid.org/0009-0001-7652-0163 Mei-Zhen Xu http://orcid.org/0009-0001-6306-3880 Ji-Ping Yang http://orcid.org/0009-0003-1610-1017
Funding Agency and Grant Number	Funding Agency Grant Number Putian Science and Technology Plan Project No. 2022SY003
Corresponding Author	Ji-Ping Yang, Chief Physician, Department of Laboratory Medicine, First Hospital of Putian, No. 449 Nanmen West Road, Chengxiang District, Putian 351100, Fujian Province, China. yjjfjptyjp2004@126.com
Key Words	Gastric cancer; Membrane anatomy; Abdominal irrigation fluid; Tumor markers; Cancer leakage
Core Tip	This study demonstrates that membrane dissection (MD) guided laparoscopic radical gastrectomy significantly reduces postoperative cancer cell leakage compared to traditional D2 lymph adenectomy. MD showed lower rates of postoperative carcinoembryonic antigen positivity (9.52% vs 26.67%) and cytokeratin-19 positivity, with surgical approach being an independent risk factor for marker positivity. While maintaining similar safety profiles, MD achieved better short-term outcomes including reduced blood loss and faster recovery, suggesting its superiority as a radical surgical approach for gastric cancer. These findings support MD as a promising technique for improving oncological outcomes in gastric cancer surgery.
Publish Date	2025-08-25 12:36
Citation	<p>Zhou JF, Qiu W, Chen JS, Yan BQ, Feng XH, Xu MZ, Yang JP. Correlation between laparoscopic radical resection and tumor markers in peritoneal irrigation fluid. <i>World J Gastrointest Surg</i> 2025; 17(8): 109155</p>
URL	https://www.wjgnet.com/1948-9366/full/v17/i8/109155.htm
DOI	https://dx.doi.org/10.4240/wjgs.v17.i8.109155

Full Article (PDF)	WJGS-17-109155-with-cover.pdf
CONSORT 2010 Statement	109155-CONSORT-2010-statement.pdf
Manuscript File	109155_Auto_Edited_073829.docx
Answering Reviewers	109155-answering-reviewers.pdf
Audio Core Tip	109155-audio.m4a
Biostatistics Review Certificate	109155-biostatistics-statement.pdf
Clinical Trial Registration Statement	109155-clinical-trial-registration-statement.pdf
Conflict-of-Interest Disclosure Form	109155-conflict-of-interest-statement.pdf
Copyright License Agreement	109155-copyright-assignment.pdf
Approved Grant Application Form(s) or Funding Agency Copy of any Approval Document(s)	109155-foundation-statement.pdf
Signed Informed Consent Form(s) or Document(s)	109155-informed-consent-statement.pdf
Institutional Review Board Approval Form or Document	109155-institutional-review-board-statement.pdf
Non-Native Speakers of English Editing Certificate	109155-non-native-speakers.pdf
Peer-review Report	109155-peer-reviews.pdf
Scientific Misconduct Check	109155-scientific-misconduct-check.png
Scientific Editor Work List	109155-scientific-editor-work-list.pdf
CrossCheck Report	109155-crosscheck-report.pdf