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Articles Published Processes
9/23/2025 6:48:58 AM | Browse: 65 | Download: 153
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Received |
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2025-05-06 07:37 |
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Peer-Review Started |
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2025-05-06 07:37 |
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First Decision by Editorial Office Director |
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2025-05-19 18:13 |
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Return for Revision |
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2025-05-20 18:55 |
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Revised |
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2025-05-25 20:35 |
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Publication Fee Transferred |
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Second Decision by Editor |
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2025-08-07 02:44 |
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Second Decision by Editor-in-Chief |
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Final Decision by Editorial Office Director |
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2025-08-08 10:25 |
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Articles in Press |
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2025-08-08 10:25 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-08-28 08:41 |
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Publish the Manuscript Online |
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2025-09-23 06:48 |
| ISSN |
2218-4333 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Oncology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Lynch syndrome association and clinicopathological features in early-onset colorectal cancers: A single-center retrospective study
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| Manuscript Source |
Invited Manuscript |
| All Author List |
Yunus Sür, Emine Özlem Gür, Fevzi Cengiz, Aslı Subaşıoğlu, İsmail Güzeliş, Sinem Demir, Aysegul Akder Sari, Mehmet Haciyanli and Osman Nuri Dilek |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Yunus Sür, MD, Department of General Surgery, İKÇÜ Atatürk Education and Research Hospital, Basin Sitesi, İzmir 35150, Türkiye. dr.yunus.sur@gmail.com |
| Key Words |
Early-onset colorectal cancer; Immunohistochemistry; Lynch syndrome; Microsatellite instability; Mismatch repair |
| Core Tip |
Lynch syndrome (LS) results from microsatellite instability (MSI). Immunohistochemistry (IHC) is a cost-effective and practical method for MSI screening. This retrospective study evaluated clinicopathological features of MSI and microsatellite-stable (MSS) tumors in early-onset colorectal cancer patients between 2014 and 2021. MSI tumors were linked to younger age, right-sided location, and fewer metastases. Genetic testing confirmed LS in 76.4% of MSI and 2.8% of MSS cases based on IHC. However, 59.5% of patients did not receive genetic counseling. While IHC is useful for MSI detection, it may not be sufficient alone. Low counseling rates emphasize the need for hospital-based surveillance programs. |
| Publish Date |
2025-09-23 06:48 |
| Citation |
Sür Y, Gür EÖ, Cengiz F, Subaşıoğlu A, Güzeliş İ, Demir S, Sari AA, Haciyanli M, Dilek ON. Lynch syndrome association and clinicopathological features in early-onset colorectal cancers: A single-center retrospective study. World J Clin Oncol 2025; 16(9): 109182 |
| URL |
https://www.wjgnet.com/2218-4333/full/v16/i9/109182.htm |
| DOI |
https://dx.doi.org/10.5306/wjco.v16.i9.109182 |
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