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11/28/2025 2:00:39 PM | Browse: 15 | Download: 56
Publication Name World Journal of Critical Care Medicine
Manuscript ID 109194
Country Brazil
Received
2025-05-06 06:30
Peer-Review Started
2025-05-06 06:31
First Decision by Editorial Office Director
2025-05-14 03:12
Return for Revision
2025-05-14 03:12
Revised
2025-06-04 18:41
Publication Fee Transferred
2025-06-07 15:53
Second Decision by Editor
2025-07-21 03:00
Second Decision by Editor-in-Chief
Final Decision by Editorial Office Director
2025-07-22 01:56
Articles in Press
2025-07-22 01:56
Edit the Manuscript by Language Editor
Typeset the Manuscript
2025-08-25 02:49
Publish the Manuscript Online
2025-11-28 14:00
ISSN 2220-3141(online)
Open Access This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Copyright The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
Article Reprints For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
Permissions For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
Publisher Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA
Website http://www.wjgnet.com
Category Critical Care Medicine
Manuscript Type Opinion Review
Article Title Giving urine biochemistry a second chance in acute kidney injury monitoring
Manuscript Source Unsolicited Manuscript
All Author List Alexandre Toledo Maciel
ORCID
Author(s) ORCID Number
Alexandre Toledo Maciel http://orcid.org/0000-0001-6043-0967
Funding Agency and Grant Number
Corresponding Author Alexandre Toledo Maciel, Head, MD, Department of Research, Imed Group, Hospital São Camilo Pompéia Adult ICU, Pompeia Avenue 1178 4 th floor, São Paulo 05022-001, São Paulo, Brazil. alexandre.toledo@imedgroup.com.br
Key Words Urine biochemistry; Urine electrolytes; Acute kidney injury; Monitoring; Urine bio-chemical approach; Fractional excretion of potassium; Urinary potassium/urinary cre-atinine concentration ratio; Urinary sodium concentration; Excreted mass of creatinine
Core Tip The utility of urine biochemistry assessment for acute kidney injury (AKI) monitoring was proposed 50 years ago, being theoretically capable of defining AKI pathophysiol-ogy and distinguishing functional (“pre-renal”) and structural (“renal”) impairments. However, the actual usefulness of urine biochemistry was never confirmed due to vari-able and controversial results among studies. In this review, alternative considerations for when to assess urine electrolytes and how to interpret their values for renal function monitoring are proposed.
Publish Date 2025-11-28 14:00
Citation

Maciel AT. Giving urine biochemistry a second chance in acute kidney injury monitoring. World J Crit Care Med 2025; 14(4): 109194

URL https://www.wjgnet.com/2220-3141/full/v14/i4/109194.htm
DOI https://dx.doi.org/10.5492/wjccm.v14.i4.109194
Full Article (PDF) WJCCM-14-109194-with-cover.pdf
Manuscript File 109194_Auto_Edited_021505.docx
Answering Reviewers 109194-answering-reviewers.pdf
Audio Core Tip 109194-audio.mp3
Conflict-of-Interest Disclosure Form 109194-conflict-of-interest-statement.pdf
Copyright License Agreement 109194-copyright-assignment.pdf
Non-Native Speakers of English Editing Certificate 109194-non-native-speakers.pdf
Peer-review Report 109194-peer-reviews.pdf
Scientific Misconduct Check 109194-scientific-misconduct-check.png
Scientific Editor Work List 109194-scientific-editor-work-list.pdf
CrossCheck Report 109194-crosscheck-report.pdf