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Articles Published Processes
7/21/2025 9:42:32 AM | Browse: 2 | Download: 19
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Received |
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2025-05-06 10:00 |
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Peer-Review Started |
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2025-05-06 10:00 |
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To Make the First Decision |
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Return for Revision |
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2025-05-16 22:53 |
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Revised |
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2025-05-28 13:01 |
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Second Decision |
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2025-06-16 02:41 |
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Accepted by Journal Editor-in-Chief |
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Accepted by Executive Editor-in-Chief |
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2025-06-16 06:40 |
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Articles in Press |
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2025-06-16 06:40 |
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Publication Fee Transferred |
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2025-05-29 11:05 |
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Edit the Manuscript by Language Editor |
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Typeset the Manuscript |
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2025-07-16 02:44 |
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Publish the Manuscript Online |
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2025-07-21 09:42 |
| ISSN |
1007-9327 (print) and 2219-2840 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
© The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
| Article Reprints |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/247
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| Permissions |
For details, please visit: http://www.wjgnet.com/bpg/gerinfo/207
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Basic Study |
| Article Title |
Translocator protein facilitates neutrophil-mediated mucosal inflammation in inflammatory bowel diseases
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| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Qiong He, Xiao-Han Wu, Dong-Lang Jiang, Ri-Tian Lin, Fang Xie, Yi-Hui Guan and Ai-Hua Fei |
| ORCID |
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| Funding Agency and Grant Number |
| Funding Agency |
Grant Number |
| National Natural Science Foundation of China |
No. 82300604 |
| Science and Technology Innovation Action Plan Star Project Application Guide/Star Project Incubation (Yangfan Special Program) of Shanghai |
No. 24YF2727600 |
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| Corresponding Author |
Ai-Hua Fei, Chief Physician, Department of General Medicine, Xinhua Hospital Affiliated to Shanghai Jiaotong University School of Medicine, No. 1665 Kongjiang Road, Yangpu District, Shanghai 200092, China. feiaihua@xinhuamed.com.cn |
| Key Words |
Inflammatory bowel disease; Ulcerative colitis; Crohn's disease; Translocator protein; Expression; Neutrophil; Intestinal inflammation; Neuroinflammation; Positron emission tomography-computed tomography; Gut-brain axis |
| Core Tip |
This research recognizes translocator protein (TSPO) as a novel biomarker and promising therapeutic target for inflammatory bowel diseases (IBD). Elevated TSPO expression was observed in neutrophils of IBD patients, along with increased reactive oxygen species (ROS) production and neutrophil extracellular trap formation. Additionally, upregulated TSPO in both the inflamed colon and brain tissue suggests its contributions to autoimmune inflammation and neuroinflammation. These findings recommend TSPO as a potential target for IBD treatment, highlighting its role in both intestinal and neurological inflammatory processes. |
| Publish Date |
2025-07-21 09:42 |
| Citation |
<p>He Q, Wu XH, Jiang DL, Lin RT, Xie F, Guan YH, Fei AH. Translocator protein facilitates neutrophil-mediated mucosal inflammation in inflammatory bowel diseases. <i>World J Gastroenterol</i> 2025; 31(27): 109239</p> |
| URL |
https://www.wjgnet.com/1007-9327/full/v31/i27/109239.htm |
| DOI |
https://dx.doi.org/10.3748/wjg.v31.i27.109239 |
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