| ISSN |
2307-8960 (online) |
| Open Access |
This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/ |
| Copyright |
The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved. |
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| Publisher |
Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA |
| Website |
http://www.wjgnet.com |
| Category |
Gastroenterology & Hepatology |
| Manuscript Type |
Retrospective Study |
| Article Title |
Estimation of pancreatic histology and likelihood of postoperative pancreatic fistula using extracellular volume fraction from contrast-enhanced computed tomography
|
| Manuscript Source |
Unsolicited Manuscript |
| All Author List |
Akihiro Nakamura, Takafumi Ogawa, Kuniya Tanaka, Yuki Takahashi, So Murai, Yuki Tashiro, Akane Wada, Yasuo Ueda, Yosuke Sasaki, Yuzo Minegishi, Kenichi Matsuo and Toshiko Yamochi |
| ORCID |
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| Funding Agency and Grant Number |
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| Corresponding Author |
Akihiro Nakamura, Doctorate Student, MD, Department of Diagnostic Pathology, Showa Medical University, 1-5-8 Hatanodai, Shinagawa-ku 1428666, Tōkyō, Japan. jarw.bn9@med.showa-u.ac.jp |
| Key Words |
Pancreas; Extracellular volume fraction; Fibrosis; Acini; Pancreatic resection; Pancreatoduodenectomy; Postoperative pancreatic fistula |
| Core Tip |
This study evaluated the utility of extracellular volume fraction (ECV), a computed tomography (CT)-based quantitative marker, in estimating pancreatic tissue composition and predicting postoperative pancreatic fistula (POPF). ECV was strongly correlated with histological fibrosis and inversely with acinar cell content. In patients undergoing pancreatoduodenectomy, low ECV (< 36%) and small main pancreatic duct diameter (≤ 2 mm) were identified as independent risk factors for POPF. These findings suggest that CT-derived ECV can noninvasively reflect pancreatic histology and may serve as a valuable preoperative imaging biomarker to stratify the risk of POPF. |
| Publish Date |
2025-08-05 08:58 |
| Citation |
<p>Nakamura A, Ogawa T, Tanaka K, Takahashi Y, Murai S, Tashiro Y, Wada A, Ueda Y, Sasaki Y, Minegishi Y, Matsuo K, Yamochi T. Estimation of pancreatic histology and likelihood of postoperative pancreatic fistula using extracellular volume fraction from contrast-enhanced computed tomography. <i>World J Clin Cases</i> 2025; 13(27): 109243</p> |
| URL |
https://www.wjgnet.com/2307-8960/full/v13/i27/109243.htm |
| DOI |
https://dx.doi.org/10.12998/wjcc.v13.i27.109243 |
